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Clinical expert consensus on the assessment and protection of pancreatic islet β-cell function in type 2 diabetes mellitus

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机构: [1]Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. [2]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China. [3]Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [4]Endocrinology Department, Sir Run Run Hospital of Nanjing Medical University, Nanjing, China. [5]Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [6]Department of Endocrine and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China. [7]National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China. [8]Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [9]Department of Endocrinology, Geriatric Hospital of Nanjing Medical University, Nanjing, China. [10]Department of Endocrinology, Changzheng Hospital, The Navy Military Medical University, Shanghai, China. [11]Department of Endocrinology, Anhui Provincial Hospital, Hefei, China. [12]Department of Endocrinology, The First People's Hospital of Changzhou, Changzhou, China. [13]Department of Endocrinology, General Hospital of Central Theater Command of Chinese People' s Liberation Army, Wuhan, China. [14]Department of Endocrinology, General Hospital, Tianjin Medical University, Tianjin, China. [15]Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China. [16]Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China. [17]Department of Endocrinology, Peking Union Medical College Hospital, Beijing, China. [18]Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, China. [19]Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai, China. [20]Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. [21]Department of Endocrinology, Guiqian International General Hospital, Guiyang 550018, China. [22]Department of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology, Wuhan, China. [23]Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China. [24]Department of Endocrinology, the Affiliated Jinling Hospital of Nanjing Medical University, General Hospital of Eastern Theater Command, Nanjing, China. [25]Department of Endocrinology, Xuzhou Central Hospital, Xuzhou, China. [26]Key Laboratory of Human Functional Genomics of Jiangsu Province, School of Basic Medical Science, Nanjing Medical University, Nanjing, China. [27]The First Clinical Medical Institute, Southern Medical University, Guangzhou, China. [28]Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China. [29]Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
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关键词: Islets β-cell Functional assessment

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Islet β-cell dysfunction is a basic pathophysiological characteristic of type 2 diabetes mellitus (T2DM). Appropriate assessment of islet β-cell function is beneficial to better management of T2DM. Protecting islet β-cell function is vital to delay the progress of type 2 diabetes mellitus. Therefore, the Pancreatic Islet β-cell Expert Panel of the Chinese Diabetes Society and Endocrinology Society of Jiangsu Medical Association organized experts to draft the "Clinical expert consensus on the assessment and protection of pancreatic islet β-cell function in type 2 diabetes mellitus." This consensus suggests that β-cell function can be clinically assessed using blood glucose-based methods or methods that combine blood glucose and endogenous insulin or C-peptide levels. Some measures, including weight loss and early and sustained euglycemia control, could effectively protect islet β-cell function, and some newly developed drugs, such as Sodium-glucose cotransporter-2 inhibitor and Glucagon-like peptide-1 receptor agonists, could improve islet β-cell function, independent of glycemic control.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

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大类 | 3 区 医学
小类 | 3 区 内分泌学与代谢
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出版当年[2023]版:
Q1 ENDOCRINOLOGY & METABOLISM
最新[2023]版:
Q1 ENDOCRINOLOGY & METABOLISM

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第一作者机构: [1]Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
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