Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women
Aim: We tested whether skeletal muscle mass is associated with insulin sensitivity, pancreatic beta-cell function, and postglucose glycemia. Methods: Appendicular skeletal muscle mass (ASM) (relative to body size, %ASM) by DXA, surrogate measures of insulin sensitivity, insulin secretion and the disposition index (insulin sensitivity adjusted insulin secretion: a product of the insulinogenic index and Matsuda insulin sensitivity index) inferred from serum insulin kinetics during a 75 g oral glucose tolerance test (OGTT) were evaluated in 168 young and 65 middle-aged women, whose BMI averaged <23.0 kg/m(2) and HbA1c <= 5.5 %. Results: In two groups of women, %ASM was associated negatively with homeostasis model assessment insulin resistance (HOMA-IR) and 2-h insulin (both p < 0.01 or less). In middle-aged women not in young women, %ASM was associated inversely with the Matsuda index (p < 0.001). In middle-aged women only, it also showed a positive association with the disposition index (p = 0.02) and inverse associations with 1-h and 2-h glucose (both p < 0.01) and area under the glucose concentration curve during OGTT (p = 0.006). On multivariate linear regression analyses, 2-h insulin emerged as a determinant of %ASM independently of HOMA-IR in young women (standardized beta: 0.287, p < 0.001, R-2 = 0.077). In middle-aged women, the Matsuda index emerged as a determinant of %ASM (standardized beta: 0.476, p < 0.001) independently of HOMA-IR, log ODI and AUCg and explained 21.3 % of %ASM variability. Post-glucose glycemia and AUCg were higher and log ODI was lower in middle-aged women with low compared with high %ASM. Conclusion: Low skeletal muscle mass (relative to body size) was associated with low insulin sensitivity in young and middle-aged Japanese women who were neither obese nor diabetic. Middle-aged women with low muscle mass had low disposition index, an early marker of inadequate pancreatic beta-cell compensation, and hence high glucose excursion. Low skeletal muscle mass may be associated with the development of type 2 diabetes at a much lower BMI in Japanese people.
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第一作者：
第一作者机构：[1]Mukogawa Womens Univ, Res Inst Nutr Sci, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan[2]Ehime Univ, Grad Sch Agr, Dept Biosci, Lab Community Hlth & Nutr, Matsuyama, Ehime, Japan
通讯作者：
通讯机构：[1]Mukogawa Womens Univ, Res Inst Nutr Sci, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan[4]Mukogawa Womens Univ, Open Res Ctr Studying Lifestyle Related Dis, Nishinomiya, Hyogo, Japan[9]Hakuhoukai Kakogawa Hosp, Dept Med, Kakogawa, Hyogo, Japan
推荐引用方式(GB/T 7714)：
Minato-Inokawa Satomi,Tsuboi-Kaji Ayaka,Honda Mari,et al.Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women[J].METABOLISM OPEN.2024,23:doi:10.1016/j.metop.2024.100306.
APA：
Minato-Inokawa, Satomi,Tsuboi-Kaji, Ayaka,Honda, Mari,Takeuchi, Mika,Kitaoka, Kaori...&Fukuo, Keisuke.(2024).Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women.METABOLISM OPEN,23,
MLA：
Minato-Inokawa, Satomi,et al."Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women".METABOLISM OPEN 23.(2024)
