个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

The different associations of serum gamma-glutamyl transferase and alanine aminotransferase with insulin secretion, β-cell function, and insulin resistance in non-obese Japanese

| 认领 | 导出 | |

文献详情

资源类型：
Pubmed体系：
作者：
Minato-Inokawa Satomi[1,2,3] ; Tsuboi-Kaji Ayaka[1,4] ; Honda Mari[5,6] ; Takeuchi Mika[1] ; Kitaoka Kaori[1,7] ; Kurata Miki[1,8] ; Wu Bin[5,9] ; Kazumi Tsutomu[1,5,10] ; Fukuo Keisuke[1,5,8] ;
机构： [1]Research Institute for Nutrition Sciences, Mukogawa Women’s University, 6‑46, Ikebiraki‑Cho, Nishinomiya, Hyogo 663‑8558, Japan. [2]Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime, Japan. [3]Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan. [4]Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan. [5]Open Research Center for Studying of Lifestyle‑Related Diseases, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan. [6]Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women’s University, Kobe, Hyogo, Japan. [7]Department of Advanced Epidemiology, Noncommunicable Disease (NCD) Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan. [8]Department of Food Sciences and Nutrition, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan. [9]Department of Endocrinology, First Afliated Hospital of Kunming Medical University, Kunming, Yunnan, China. [10]Department of Medicine, Kohan Kakogawa Hospital, Kakogawa, Hyogo, Japan
出处：
DOI： 10.1038/s41598-024-70396-5

关键词： Gamma-glutamyl transferase ALT/AST glucose-stimulated insulin secretion Insulin resistance β-cell function Japanese people

摘要：
The present study investigated the associations of serum gamma-glutamyl transferase (GGT), a marker of fatty liver and oxidative stress, and ALT/AST, a marker of fatty liver, with percentage trunk fat and postload glucose, insulin resistance, and β-cell function in middle-aged Japanese individuals, whose BMI averaged < 23.0 kg/m2. Pancreatic β-cell function was assessed using the disposition index calculated by a product of the insulinogenic index (IGI) and Matsuda insulin sensitivity index, a biomarker of early-phase glucose-stimulated insulin secretion and whole-body insulin sensitivity, respectively. Multivariate linear regression analyses revealed that the disposition index was associated inversely with GGT independently of percentage trunk fat, homeostasis model assessment insulin resistance (HOMA-IR), a marker of insulin resistance, and Matsuda index. When IGI was included instead of the disposition index, IGI (inversely) and HOMA-IR were associated with GGT independently of percentage trunk fat and Matsuda index. When the area under the glucose concentration curve (AUCg) during an oral glucose tolerance test was included instead of the disposition index, AUCg and HOMA-IR emerged as independent determinants of GGT. ALT/AST was associated with HOMA-IR alone. Results suggest a different pathophysiologic basis between GGT and ALT/AST in predicting diabetic risk in non-obese Japanese.© 2024. The Author(s).

语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
无
最新[2023]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
第一作者：
第一作者机构： [1]Research Institute for Nutrition Sciences, Mukogawa Women’s University, 6‑46, Ikebiraki‑Cho, Nishinomiya, Hyogo 663‑8558, Japan. [2]Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime, Japan. [3]Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.
通讯作者：
通讯机构： [1]Research Institute for Nutrition Sciences, Mukogawa Women’s University, 6‑46, Ikebiraki‑Cho, Nishinomiya, Hyogo 663‑8558, Japan. [5]Open Research Center for Studying of Lifestyle‑Related Diseases, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan. [10]Department of Medicine, Kohan Kakogawa Hospital, Kakogawa, Hyogo, Japan
推荐引用方式(GB/T 7714)：
Minato-Inokawa Satomi,Tsuboi-Kaji Ayaka,Honda Mari,et al.The different associations of serum gamma-glutamyl transferase and alanine aminotransferase with insulin secretion, &#x3b2;-cell function, and insulin resistance in non-obese Japanese[J].Scientific Reports.2024,14(1):19234.doi:10.1038/s41598-024-70396-5.
APA：
Minato-Inokawa Satomi,Tsuboi-Kaji Ayaka,Honda Mari,Takeuchi Mika,Kitaoka Kaori...&Fukuo Keisuke.(2024).The different associations of serum gamma-glutamyl transferase and alanine aminotransferase with insulin secretion, &#x3b2;-cell function, and insulin resistance in non-obese Japanese.Scientific Reports,14,(1)
MLA：
Minato-Inokawa Satomi,et al."The different associations of serum gamma-glutamyl transferase and alanine aminotransferase with insulin secretion, &#x3b2;-cell function, and insulin resistance in non-obese Japanese".Scientific Reports 14..1(2024):19234

相关文献

[1]Associations of adipose insulin resistance index with pancreatic β cell function (inverse) and glucose excursion (positive) in young Japanese women [2]Low muscle mass is associated with low insulin sensitivity, impaired pancreatic β cell function, and high glucose excursion in nondiabetic nonobese Japanese women [3]细胞因子在胰岛素抵抗中的作用 [4]Effect of Insulin-Regulated FOXC2 Expression in Adipocyte Differentiation and Insulin Resistance. [5]Effect of Different Interventions on Glycemic Control and β-cell Function in Newly Diagnosed Type 2 Diabetic Patients [6]Insulin resistance is associated with Sfrp5 in obstructive sleep apnea [7]Determinants and correlates of adipose tissue insulin resistance index in Japanese women without diabetes and obesity [8]Humanin alleviates insulin resistance in polycystic ovary syndrome: a human and rat model-based study. [9]EGCG与胰岛素抵抗 [10]Higher circulating orosomucoid, an acute-phase protein, and reduced glucose-induced insulin secretion in middle-aged Japanese people with prediabetes.

资源点击量：52537 今日访问量：0 总访问量：1562 更新日期：2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 昆明医科大学第一附属医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西昌路295号(650032)