机构：[1]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.昆明医科大学附属第一医院[2]Department of Rheumatology and Immunology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.[3]Department of Acute Infectious Disease prevention and Control, Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, China.[4]Department of Nephrology, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.云南省第一人民医院[5]Department of Disease Control and Prevention, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.云南省第一人民医院
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. At present, the mechanism of non-coding RNA in renal injury in SLE patients is still unclear. A total of 64 DEcircRNAs, 75 DEmiRNAs, and 249 DEmRNAs were identified. We integrated 10 circRNAs, 10 miRNAs, and 88 target mRNAs into a circRNA-miRNA-mRNA network and obtained 9 hub genes (circ-0000006, miR-766-3p, miR-409-3p, miR-339-3p, miR-331-3p, miR-140-3p, miR-186-5p, miR-149-5p, PSME3). The ROC curve results showed that the diagnostic efficiency of 6 hub miRNA was higher than that of has_circ_0000006 and PSEME3. SsGSEA analysis revealed immune cell composition in SLE and control renal tissues, including 3 types of immune cells up-regulated (gamma delta T cell, effector memory CD4 T cell, central memory CD8 T cell) and 4 types down-regulated (memory B cell, mast cell, macrophage, immature dendritic cell, eosinophil) in SLE patients. In addition, PSME3 was negatively correlated with 3 up-regulated immune cells and positively correlated with 4 down-regulated immune cells in SLE patients. Our study provides a deeper understanding of the circRNA-related competing endogenous RNA regulatory mechanism in the renal injury of systemic lupus erythematosus.
基金：
Intra-Hospital Doctoral Fund (KHBS-2022-027); National Natural Science Foundation of China Regional Funds (82060305, 82160696).
第一作者机构：[1]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
共同第一作者：
通讯作者：
通讯机构：[4]Department of Nephrology, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.[5]Department of Disease Control and Prevention, The First People's Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.[*1]Department of Nephrology, The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming, Yunnan Province 650034, China[*2]Department of Disease Control and Prevention, The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming, Yunnan Province 650034, China.
推荐引用方式(GB/T 7714)：
Li Ya,Chen Juan,Xie Min,et al.Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on renal injury in systemic lupus erythematosus[J].AUTOIMMUNITY.2023,56(1):2193361.doi:10.1080/08916934.2023.2193361.
APA：
Li Ya,Chen Juan,Xie Min,Cao Yihui,Zhou Yan&Zhang Ruixian.(2023).Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on renal injury in systemic lupus erythematosus.AUTOIMMUNITY,56,(1)
MLA：
Li Ya,et al."Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on renal injury in systemic lupus erythematosus".AUTOIMMUNITY 56..1(2023):2193361
