机构：[1]School of Basic Medical Sciences, Dali University, Dali, China[2]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China内科科室皮肤科昆明医科大学附属第一医院
Severe acne is a chronic inflammatory skin condition that is affected by both genetic and environmental factors. DNA methylation is associated with a variety of inflammatory skin diseases, but its role in severe acne is unclear. In this study, we conducted a two-stage epigenome correlation study using 88 blood samples to identify disease-related differential methylation sites. We found close associations between the DNA methylation at 23 differentially methylated sites (DMSs) and severe acne, including PDGFD, ARHGEF10, etc. Further analysis revealed that differentially methylated genes (PARP8 and MAPKAPK2) were also expressed differently between severe acne and health control groups. These findings lead us to speculation that epigenetic mechanisms may play an important role in the pathogenesis of severe acne.
基金：
National Natural Science Foundation of China [81760565, 82160600]; Youth Top Talent project of High-level talent development support program of Yunnan Province [YNWR-QNBJ-2020-239]; Li Yunqing expert workstation of Yunnan Province [202005AF150014]
第一作者机构：[1]School of Basic Medical Sciences, Dali University, Dali, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Basic Medical Sciences, Dali University, Dali, China[2]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China[*1]School of Basic Medical Sciences, Dali University, Dali, China[*2]Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China
推荐引用方式(GB/T 7714)：
Wang Huai,Dang Tianyuan,Feng Jiaqi,et al.Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis[J].EPIGENETICS.2023,18(1):doi:10.1080/15592294.2023.2199373.
APA：
Wang, Huai,Dang, Tianyuan,Feng, Jiaqi,Wu, Wenjuan,He, Li&Yang, Jiankang.(2023).Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis.EPIGENETICS,18,(1)
MLA：
Wang, Huai,et al."Identification of differentially methylated genes for severe acne by genome-wide DNA methylation and gene expression analysis".EPIGENETICS 18..1(2023)
