机构:[1]Shandong Daizhuang Hospital, Jining, China.[2]Jining Medical University, Jining, China.[3]Xiamen Xianyue Hospital, China.[4]Affiliated Hospital of Jining Medical University, China.[5]The First Affiliated Hospital of Kunming Medical University, China.昆明医科大学附属第一医院
We conducted an updated coordinate-based meta-analysis (CBMA) to determine the most prominent and robust white matter (WM) abnormalities in ADHD based on tract-based spatial statistics (TBSS) findings.The seed-based d mapping (SDM) software was applied to compare regional fractional anisotropy (FA) alterations in ADHD. Subgroup meta-analyses in the pure ADHD without comorbidity subgroup, the children and adolescents subgroup, and the adults subgroup were also explored, respectively. Meta-regression analysis was subsequently used to examine potential correlations between demographics and FA changes.Only one cluster in the splenium of corpus callosum (CC) exhibited age-related FA decrease in ADHD individuals in the pooled meta-analysis. The adults ADHD subgroup revealed two clusters with reduced FA lied in the splenium and body of CC.This updated CBMA confirmed the WM abnormalities in the splenium of CC in ADHD, and improved our understanding of the pathogenesis of this neurodevelopmental disorder.
基金:
Medical and Health Science and Technology
Development Plan of Shandong Province (202003061210,
202203090679), the Key Research and Development Plan of Jining
City (2021YXNS024), the Cultivation Plan of High-level Scientific
Research Projects of Jining Medical University (JYGC2021KJ006),
the National Natural Science Foundation of China (81901358), the
Natural Science Foundation of Shandong Province (ZR2019BH001
and ZR2021YQ55), the Young Taishan Scholars of Shandong
Province (tsqn201909146), and the Supporting Fund for Teachers’
Research of Jining Medical University (600903001).
通讯机构:[1]Shandong Daizhuang Hospital, Jining, China.[2]Jining Medical University, Jining, China.[4]Affiliated Hospital of Jining Medical University, China.[*1]Department of Psychiatry, Shandong Daizhuang Hospital, Jidai Road, Jining 272051, China.[*2]School of Mental Health, Jining Medical University, Jianshe Road, Jining 272067, China.
推荐引用方式(GB/T 7714):
Cui Jian,Wang Zhonggang,Xu Yinghong,et al.Altered White Matter Integrity in ADHD Revealed by Meta-analysis of Tract-based Spatial Statistics[J].JOURNAL OF ATTENTION DISORDERS.2023,27(9):997-1008.doi:10.1177/10870547231167499.
APA:
Cui Jian,Wang Zhonggang,Xu Yinghong,Li Ying,Yu Hao...&Zhou Cong.(2023).Altered White Matter Integrity in ADHD Revealed by Meta-analysis of Tract-based Spatial Statistics.JOURNAL OF ATTENTION DISORDERS,27,(9)
MLA:
Cui Jian,et al."Altered White Matter Integrity in ADHD Revealed by Meta-analysis of Tract-based Spatial Statistics".JOURNAL OF ATTENTION DISORDERS 27..9(2023):997-1008