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Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer

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机构： [1]Institute of Basic Medical and Forensic Medicine, North Sichuan Medical College, Nanchong, China. [2]Animal Experimental Center, North Sichuan Medical College, Nanchong, China. [3]School of Clinical Medicine, North Sichuan Medical College, Nanchong, China. [4]School of Pharmacy, North Sichuan Medical College, Nanchong, China. [5]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China.

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关键词： AMPK brexpiprazole colorectal cancer lipogenesis SREBP1

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In the present study, we investigated the role of brexpiprazole on cell proliferation and lipogenesis in colorectal cancer (CRC) and its molecular mechanism.The effect of brexpiprazole on CRC cell proliferation was determined by CCK-8, EdU assay, cell clone formation. The flow cytometry was evaluated cell cycle. Differential expression genes (DEGs) were identified by RNA-seq assay after treating HCT116 cells with or without 20 μM brexpiprazole for 24 h. Then, the top 120 DEGs were analyzed by GO and KEGG enrichment analysis. After that, Oil red O staining and the levels of total cholestenone and triglyceride were measured to assess lipogenesis capacity in CRC cells. The related molecules of cell proliferation, lipogenic and AMPK/SREBP1 signal pathways were measured by q-PCR, western blot and immunohistochemical staining.Brexpiprazole remarkably suppressed cell proliferation, lipogenesis, and induced cell cycle arrest in CRC. The underlying mechanisms probably involved the suppression of SREBP1 and the stimulation of AMPK.Brexpiprazole inhibited cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in CRC.© 2023 Wiley Periodicals LLC.

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最新[2023]版：

大类 | 3 区医学

小类 | 2 区环境科学 2 区毒理学 2 区水资源

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出版当年[2023]版：

Q1 WATER RESOURCES Q1 TOXICOLOGY Q2 ENVIRONMENTAL SCIENCES

最新[2023]版：

Q1 WATER RESOURCES Q1 TOXICOLOGY Q2 ENVIRONMENTAL SCIENCES

影响因子： 4.4 最新[2023版] 4.2 最新五年平均 4.4 出版当年[2023版] 4.2 出版当年五年平均 4.5 出版前一年[2022版]

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第一作者机构： [1]Institute of Basic Medical and Forensic Medicine, North Sichuan Medical College, Nanchong, China.

通讯作者：

通讯机构： [1]Institute of Basic Medical and Forensic Medicine, North Sichuan Medical College, Nanchong, China. [5]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China. [*1]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China. [*2]Institute of Basic Medical and Forensic Medicine, North Sichuan Medical College, Nanchong 637100, China.

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