机构：[1]Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.[2]Guangzhou National Laboratory, Guangzhou, China.[3]Department of Pediatrics, Yinchuan Maternal and Child Health Care Hospital, Yinchuan, China.[4]Department of Pediatrics, Gansu Provincial Hospital, Lanzhou, China.[5]Department of Allergy, State Grid Beijing Electric Power Hospital, Capital Medical University Electric Power Teaching Hospital, Beijing, China.[6]Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Wulumuqi, China.[7]Laboratory of Allergy and Precision Medicine, Chengdu Institute of Respiratory Health, the Third People's Hospital of Chengdu, Chengdu, China.[8]Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming, China.内科科室儿科昆明医科大学附属第一医院[9]Department of Respiratory, The Second People's Hospital of Zhaoqing, Zhaoqing, China.[10]Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.[11]Department of Allergy and Clinical Immunology, Inner Mongolia Cancer Hospital, Inner Mongolia, China.[12]Department of Clinical Lab, Dongguan Eighth People's Hospital, Dongguan, China.[13]Department of Allergy and Clinical Immunology, Henan Provincial People's Hospital, Zhengzhou, China.[14]Department of Otolaryngology, Foshan Maternal Child Health Hospital, Foshan, China.[15]Department of Allergy, The First Affiliated Hospital of Harbin Medical University, Harbin, China.[16]Department of Clinical Laboratory, Shenzhen Pingle Orthopedic Hospital (Shenzhen Pingshan Traditional Chinese Medicine Hospital), Shenzhen, China.深圳平乐骨伤科医院深圳市康宁医院深圳医学信息中心[17]KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China.[18]Department of Respirology, Children's Hospital, Soochow University, Suzhou, China.
Few risk-forecasting models of allergic rhinitis (AR) exist that may aid AR pre-exposure prophylaxis (PrEP) in clinical practice. Therefore, this study aimed to develop and validate an effective clinical model for identifying candidates for AR PrEP using a routine medical questionnaire.This study was conducted in 10 Chinese provinces with 13 medical centers (n = 877) between 2019 and 2021. Clinical characteristics and exposure history were collected via face-to-face interviews. Well-trained physicians diagnosed patients with AR based on skin prick test results and clinical performance. The least absolute shrinkage and selection operator model was used to identify potential risk factors for AR, and the logistic regression model was used to construct the risk-forecasting model. Predictive power and model reliability were assessed using area under the receiver operating characteristic curve and calibration curves, respectively.This study diagnosed 625 patients with AR who had positive responses to at least one indoor or outdoor allergen and 460 to at least one outdoor pollen allergen. Two nomograms were established to identify two types of AR with various sensitization patterns. Both models had an area under curve of approximately 0.7 in the development and internal validation datasets. Additionally, our findings found good agreement for the calibration curves of both models.Early identification of candidates for AR PrEP using routine medical information may improve the deployment of limited resources and effective health management. Our models showed good performance in predicting AR; therefore, they can serve as potential automatic screening tools to identify AR PrEP candidates.
基金：
This study was supported by the Foundation of the State Key Laboratory of Respiratory Disease [Z-2022-09], Guangzhou Science and Technology Foundation [2023A03J0365], ZNSXS[20220015, 20220042], the Medical Scientific Research Foundation of Guangdong Province [Project Number: B2021375]. Part of this work was supported by Foundation of Guangdong Research Institute-China Engineering Science and Technology Development Strategic Project (2023-GD-04).
第一作者机构：[1]Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.[2]Guangzhou National Laboratory, Guangzhou, China.[18]Department of Respirology, Children's Hospital, Soochow University, Suzhou, China.[*1]Department of Clinical Laboratory, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China[*2]Department of Respirology, Children’s Hospital, Soochow University, Suzhou, China
推荐引用方式(GB/T 7714)：
Luo Wenting,Hou Xiangqing,Sun Yun,et al.Developing and validating clinical models to identify candidates for allergic rhinitis pre-exposure prophylaxis[J].ANNALS OF MEDICINE.2023,55(2):doi:10.1080/07853890.2023.2287188.
APA：
Luo Wenting,Hou Xiangqing,Sun Yun,Zhang Hong,Ren Huali...&Sun Baoqing.(2023).Developing and validating clinical models to identify candidates for allergic rhinitis pre-exposure prophylaxis.ANNALS OF MEDICINE,55,(2)
MLA：
Luo Wenting,et al."Developing and validating clinical models to identify candidates for allergic rhinitis pre-exposure prophylaxis".ANNALS OF MEDICINE 55..2(2023)
