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Enrichment process, structural prediction, isolation, in vitro cytotoxic and anti-inflammatory effects of triterpenoid saponins in Camellia japonica L. leaves water extract through UPLC-Q-TOF based mass spectrometry similarity networking

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收录情况： ◇ SCIE

作者：
Liu Hui[1,2] ; Bi Lisha[1,2,3] ; Chen Qirun[1,2] ; He Xiaozhi[1,2,3] ; Yan Huan[1,2,3] ; Ni Wei[1,2] ; Wu Wenjuan[4] ; He Li[1,5,*1] ; Liu Haiyang[1,2,*2] ;
机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [2]Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China [3]University of Chinese Academy of Sciences, Beijing 100039, China [4]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [5]Skin Health Research Center, Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China
出处：
DOI： 10.1016/j.foodchem.2024.138360
ISSN：

关键词： Camellia japonica L Triterpenoid saponin UPLC-Q-TOF Molecular networking Anticancer effect

摘要：
Camellia japonica L. is rich in bioactive compounds, but its health-enhancing potential is often overshadowed by its ornamental value. Notably, triterpenoid saponins are prominent due to their surfactant properties. MolNetEnhancer revealed 537 compounds in C. japonica leaves water extract, classified into 32 categories, including 38 triterpenoid saponins. To enrich triterpenoid saponins, the process of D101 resin chromatography was employed. Molecular networking analysis based on UPLC-Q-TOF and quantitative analysis based on HPLC revealed saponins concentrated in fractions 3 and 4 (68.3% transfer). MS2LDA and NAP predicted structures for 38 triterpenoid saponins, revealing nearly half of them are potential new compounds. Comprehensive chromatographic and spectroscopic methods were used for purification and structural illustration of triterpenoid saponins, yielding 13, including 7 new compounds. Statistical analysis and in vitro assays revealed the cytotoxic and anti-inflammatory activities of these triterpenoid saponins played a crucial role in the anticancer effects.Copyright © 2024 Elsevier Ltd. All rights reserved.

基金：
This work received financial support from the National Natural Science Foundation of China (32170408 and 32000280), the Yunnan Revitalization Talent Support Program “Top Team” Project (202305AT350001), the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents (YNWR-CYJS-2019-011), the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001), the National Key Research and Development Program of China (2022YFF1100301), the Special Research Assistant of Chinese Academy of Sciences (E3292211Q1 for Hui Liu), the Yunnan Postdoctoral Research Fund (E33S4212 for Hui Liu), and the Yunnan Provincial Postdoctoral Targeted Training and Support Program (E33O323261 for Hui Liu).
语种：
外文
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出版当年[2025]版：
无
最新[2023]版：
大类 | 1 区 农林科学
小类 | 1 区 应用化学 1 区 食品科技 1 区 营养学
JCR分区：
出版当年[2024]版：
无
最新[2023]版：
Q1 CHEMISTRY, APPLIED Q1 FOOD SCIENCE & TECHNOLOGY Q1 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [2]Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [2]Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China [5]Skin Health Research Center, Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China [*1]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [*2]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
推荐引用方式(GB/T 7714)：
Liu Hui,Bi Lisha,Chen Qirun,et al.Enrichment process, structural prediction, isolation, in vitro cytotoxic and anti-inflammatory effects of triterpenoid saponins in Camellia japonica L. leaves water extract through UPLC-Q-TOF based mass spectrometry similarity networking[J].FOOD CHEMISTRY.2024,441:138360.doi:10.1016/j.foodchem.2024.138360.
APA：
Liu Hui,Bi Lisha,Chen Qirun,He Xiaozhi,Yan Huan...&Liu Haiyang.(2024).Enrichment process, structural prediction, isolation, in vitro cytotoxic and anti-inflammatory effects of triterpenoid saponins in Camellia japonica L. leaves water extract through UPLC-Q-TOF based mass spectrometry similarity networking.FOOD CHEMISTRY,441,
MLA：
Liu Hui,et al."Enrichment process, structural prediction, isolation, in vitro cytotoxic and anti-inflammatory effects of triterpenoid saponins in Camellia japonica L. leaves water extract through UPLC-Q-TOF based mass spectrometry similarity networking".FOOD CHEMISTRY 441.(2024):138360

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