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A novel LINC02321 promotes cell proliferation and decreases cisplatin sensitivity in bladder cancer by regulating RUVBL2

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机构： [1]Department of Urology, The 1st Affiliated Hospital of Kunming Medical University, Kunming 650032, China [2]Yunnan Province Clinical Research Center for Chronic Kidney Disease, Kunming 650032, China

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关键词： Bladder cancer LncRNAs Cellular biology Cell cycle Chemotherapy

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Bladder cancer (BC) has a high incidence and is prone to recurrence. In most instances, the low 5-year survival rate of advanced BC patients results from postoperative recurrence and drug resistance. Long noncoding RNAs (lncRNAs) can participate in numerous biological functions by regulating the expression of genes to affect tumorigenesis. Our previous work had demonstrated that a novel lncRNA, LINC02321, was associated with BC prognosis. In this study, A high expression of LINC02321 was found in BC tissues, which was associated with poor prognosis in patients. LINC02321 promoted both proliferation and G1-G0 progression in BC cells, while also inhibited sensitivity to cisplatin. Mechanistically, LINC02321 can bind to RUVBL2 and regulate the expression levels of RUVBL2 protein by affecting its half-life. RUVBL2 is involved in the DNA damage response. The potential of DNA damage repair pathways to exert chemosensitization has been demonstrated in vivo. The rescue experiment demonstrated that RUVBL2 overexpression can markedly abolish the decreased cell proliferation and the increased sensitivity of BC cells to cisplatin caused by LINC02321 knockdown. The results indicate that LINC02321 functions as an oncogene in BC, and may serve as a novel potential target for controlling BC progression and addressing cisplatin resistance in BC therapy.Copyright © 2024. Published by Elsevier Inc.

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大类 | 2 区医学

小类 | 3 区肿瘤学

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最新[2023]版：

Q1 ONCOLOGY

影响因子： 4.5 最新[2023版] 4.2 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 4.5 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Urology, The 1st Affiliated Hospital of Kunming Medical University, Kunming 650032, China [2]Yunnan Province Clinical Research Center for Chronic Kidney Disease, Kunming 650032, China

通讯作者：

通讯机构： [1]Department of Urology, The 1st Affiliated Hospital of Kunming Medical University, Kunming 650032, China [2]Yunnan Province Clinical Research Center for Chronic Kidney Disease, Kunming 650032, China

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