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Neoantigen immunotherapy: a novel treatment for bladder cancer

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机构： [1]Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China. [2]Department of Cardiovascular, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116027, China. [3]Department of Urology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China. [4]Department of Nursing, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China. [5]Department of Anesthesiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China.

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关键词： Bladder cancer immunotherapy neoantigens

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Bladder cancer is currently the most common malignant tumor of the urinary system. The traditional treatment methods for bladder cancer are mainly surgery, chemotherapy, radiotherapy, and targeted therapy; however, these treatment methods do not improve the clinical prognosis of patients with advanced or metastatic bladder cancer. Consequently, there is an urgent need to develop new treatment methods to improve the survival rate and quality-of-life of patients with bladder cancer. Over recent years, the rapid development of tumor immunotherapy has become a significant alternative to traditional treatment, and provides new hope to patients. This review aims to introduce neoantigens and their possible role in the treatment of bladder cancer, and to explore the current limitations of neoantigens for the treatment of bladder cancer.© The Author(s) 2025.

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第一作者机构： [1]Department of Urology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116021, China.

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