机构：[1]Department of Plastic Surgery, The First People’s Hospital of Lianyungang, Lianyungang, China,[2]Department of Plastic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China外科科室整形外科昆明医科大学附属第一医院
Background: To elucidate the potential biological function of hsa_circ_0062270 in the malignant process of melanoma and its potential target.Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to examine relative level of hsa_circ_0062270 in melanoma tissues and normal skin tissues. The diagnostic and prognostic potentials of hsa_circ_0062270 in melanoma were evaluated. The regulatory effect of hsa_circ_0062270 on the expression of linear transcript Cell division cycle protein 45 (CDC45) was also examined.Results: Hsa_circ_0062270 was up-regulated in melanoma samples and cell lines, which displayed certain diagnostic and prognostic potentials in melanoma. Inhibition of hsa_circ_0062270 attenuated the proliferative, migratory and invasive functions. Hsa_circ_0062270 could stabilize the expression of linear transcript CDC45, and thus participated in the malignant process of melanoma.Conclusion: Hsa_circ_0062270 promotes proliferative, migratory and invasive functions of melanoma cells via stabilizing the linear transcript CDC45. Hsa_circ_0062270 can be used to diagnosis and treatment of melanoma.
第一作者机构：[1]Department of Plastic Surgery, The First People’s Hospital of Lianyungang, Lianyungang, China,
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通讯作者：
推荐引用方式(GB/T 7714)：
Wei Cuie,Sun Wentao,Liu Changhai,et al.Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45[J].FRONTIERS IN GENETICS.2022,13:doi:10.3389/fgene.2022.897440.
APA：
Wei, Cuie,Sun, Wentao,Liu, Changhai,Meng, Fanjun,Sun, Lele&Ding, Xiangsheng.(2022).Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45.FRONTIERS IN GENETICS,13,
MLA：
Wei, Cuie,et al."Hsa_circ_0062270 Promotes Tumorigenesis of Melanoma by Stabilizing the Linear Transcript Cell Division Cycle Protein 45".FRONTIERS IN GENETICS 13.(2022)
