Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is the first enzyme in the de novo purine nucleotide synthesis pathway and is essential for cell development. However, the effect of PRPS1 on melanoma proliferation and metastasis remains unclear. This study aimed to investigate the regulatory mechanism of PRPS1 in the malignant progression of melanoma. Here, we found PRPS1 was upregulated in melanoma and melanoma cells. In addition, our data indicated that PRPS1 could promote the proliferation and migration and invasion of melanoma both in vitro and in vivo. PRPS1 also could inhibit melanoma cell apoptosis. Furthermore, we found NRF2 is an upstream transcription factor of PRPS1 that drive malignant progression of melanoma.
基金：
National Natural Science Foundation of China; [31960200]; [31660246]; [82160540]
第一作者机构：[1]Kunming Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Kunming, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Xiong Guohang,Feng Yu,Yi Xiaojia,et al.NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma[J].FRONTIERS IN IMMUNOLOGY.2022,13:doi:10.3389/fimmu.2022.989263.
APA：
Xiong, Guohang,Feng, Yu,Yi, Xiaojia,Zhang, Xuedan,Li, Xiaoyu...&Zhu, Yuechun.(2022).NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.FRONTIERS IN IMMUNOLOGY,13,
MLA：
Xiong, Guohang,et al."NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma".FRONTIERS IN IMMUNOLOGY 13.(2022)
