机构:[1]Kunming Med Univ,Affiliated Hosp 1,Dept Anesthesiol,Kunming,Yunnan,Peoples R China昆明医科大学附属第一医院外科科室麻醉手术科(医技)[2]Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu, Peoples R China四川大学华西医院
Purpose Cardiovascular disease remains the leading cause of death worldwide. Dexmedetomidine is a highly selective a2 adrenergic receptor agonist with sedative, analgesic, anxiolytic, and sympatholytic properties, and several studies have shown its possible protective effects in cardiac injury. The aim of this review is to further elucidate the underlying cardioprotective mechanisms of dexmedetomidine, thus suggesting its potential in the clinical management of cardiac injury. Results and conclusion Our review summarizes the findings related to the involvement of dexmedetomidine in cardiac injury and discusses the results in the light of different mechanisms. We found that numerous mechanisms may contribute to the cardioprotective effects of dexmedetomidine, including the regulation of programmed cell death, autophagy and fibrosis, alleviation of inflammatory response, endothelial dysfunction and microcirculatory derangements, improvement of mitochondrial dysregulation, hemodynamics, and arrhythmias. Dexmedetomidine may play a promising and beneficial role in the treatment of cardiovascular disease.
基金:
This study was funded by the National Natural Science
Foundation of China (82060060), Joint Special Key Fund of Applied
Fundamental Research of Kunming Medical University granted by
Science and Technology Office of Yunnan (202201AY070001-040),
Yunnan Health Training Project of High Levels Talents (L-2018007),and Yunnan Provincial Ten Thousand-Talent Program-Famous Doctor
(YNWR-MY-2018-043).
第一作者机构:[1]Kunming Med Univ,Affiliated Hosp 1,Dept Anesthesiol,Kunming,Yunnan,Peoples R China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Jiang Leyu,Xiong Wei,Yang Yuqiao,et al.Insight into Cardioprotective Effects and Mechanisms of Dexmedetomidine[J].CARDIOVASCULAR DRUGS AND THERAPY.2024,doi:10.1007/s10557-024-07579-9.
APA:
Jiang, Leyu,Xiong, Wei,Yang, Yuqiao&Qian, Jinqiao.(2024).Insight into Cardioprotective Effects and Mechanisms of Dexmedetomidine.CARDIOVASCULAR DRUGS AND THERAPY,,
MLA:
Jiang, Leyu,et al."Insight into Cardioprotective Effects and Mechanisms of Dexmedetomidine".CARDIOVASCULAR DRUGS AND THERAPY .(2024)