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The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients

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机构: [1]Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China [2]Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, National Centerfor STD Control, Centers for Disease Control and Prevention, Nanjing, China [3]Department of Dermatology,The fifth People’s Hospital of Suzhou, Suzhou, China [4]Department of Dermatology, Xi ’an North Hospital, Xian,China [5]Department of venereal Diseases, Dalian Dermatology Hospital, Dalian, China [6]Department of ClinicalLaboratory, West China Hospital, Sichuan University, Chengdu, China [7]Department of Dermatology, First Hospitalof Jilin University, Jilin, China [8]Department of Dermatology, Dermatology Hospital of Southern Medical University,Guangzhou, China [9]Department of Dermatology, The Second Hospital of Shanxi Medical University, Taiyuan,China [10]Department of Clinical Laboratory, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, China [11]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, China [12]Department of Dermatology, Guangxi Zhuang Autonomous Region Dermatology Hospital, Nanning, China [13]Department of Dermatology, Chongqing First People’s Hospital, Chongqing, China [14]Department of infectiousdiseases, Chongqing Public health treatment Service center, Chongqing, China [15]Department of Dermatology,Nantong Fourth People’s Hospital, Nantong, China [16]Department of Dermatology, Nanjing Second Hospital,Nanjing, China [17]Department of Clinical Laboratory, Zhejiang Institute of Dermatology Prevention and Treatment,Huzhou, China [18]Department of Dermatology, Xuzhou First People’s Hospital, Xuzhou, China [19]Departmentof Dermatology, Wuxi Second People’s Hospital, Wuxi, China [20]Department of Dermatology, Angang GroupGeneral Hospital, Anshan, China [21]Department of Dermatology, Jingzhou First People’s Hospital, Jingzhou, China [22]Department of Dermatology, Tongji Medical College, The Central hospital of Wuhan, Huazhong University ofScience and Technology, Wuhan, China
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关键词: Neurosyphilis Diagnostic criteria Sensitivity Specificity HIV-negative

摘要:
Diagnosing neurosyphilis in clinical settings poses significant challenges due to the absence of highly efficient diagnostic criteria. Our objective was to enhance the existing diagnostic criteria and assess their sensitivity and specificity for identifying neurosyphilis in HIV-negative patients. We conducted a retrospective review of patient records from a cross-sectional study carried out between December 2019 and May 2023. This study was designed to explore clinical practices in the diagnosis and treatment of neurosyphilis. We proposed and validated a new set of diagnostic criteria across 782 cases, comparing three different NS criteria for diagnostic efficiency. Among the 782 patients analyzed, 410 were diagnosed with neurosyphilis, while 372 were not. The newly developed NS criteria demonstrated a sensitivity of 99.5% and a specificity of 94.6%, with the added benefit of being user-friendly. In subgroups categorized by neurological symptoms and syphilis stages, the new NS criteria also exhibited high sensitivity and specificity. Statistical analyses confirmed that the novel NS criteria performed comparably well to the expanded NS criteria. The novel NS criteria for HIV-negative patients exhibited high sensitivity and specificity, proving to be both effective and convenient for physicians to implement.© 2024. The Author(s).

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大类 | 2 区 综合性期刊
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Q1 MULTIDISCIPLINARY SCIENCES

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第一作者机构: [1]Department of Dermatology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
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