机构:[1]Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.内科科室呼吸内科昆明医科大学附属第一医院呼吸与危重症一科呼吸内科内科科室[2]Clinical Medicine, 2015 & 2017 Grade, Kunming Medical University, Kunming, China.[3]Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京友谊医院
Background:
Obstructive sleep apnea (OSA) is a serious threat to individual health. Diagnosis of OSA is mainly polysomnography (PSG). However, PSG monitoring is costly and time-consuming. At present, increasing studies are exploring new diagnostic methods for OSA. This study aimed to explore the diagnostic role of Sestrin2 in OSA.
Materials and Methods:
Sixty-four subjects were recruited in this study. The concentration of plasma Sestrin2 of all subjects were measured and compared. Spearman's correlation analysis was used to investigate the correlation between plasma Sestrin2 concentration and other factors. Receiver-operating characteristic (ROC) curve was used to investigate the role of Sestrin2 in the diagnosis of OSA, moderate-severe and severe OSA.
Results:
Subjects were divided into OSA group (n = 38) and control (n = 26). Levels of Plasma Sestrin2 were significantly higher in OSA patients than in controls. Sestrin2 was positively correlated with oxygen reduction index and negatively correlated with mean oxygen saturation and lowest oxygen saturation. The area under ROC curve (AUC) of Sestrin2 for OSA diagnosis was 0.740 [95% confidence interval (CI), 0.615-0.842], the cutoff value was 1.86 ng/mL, and the sensitivity and specificity were 81.58% and 61.54%, respectively. The AUC of Sestrin2 for the diagnosis of severe OSA was 0.801 (95% CI, 0.682-0.890), and the cutoff value was 5.21 ng/mL exhibiting the sensitivity and specificity of 61.90% and 90.70%, respectively.
Conclusion:
Setrin2 is a marker for OSA and may be helpful in the diagnosis of OSA.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81560589, 30960450, 81173110, 81402991]; Yunnan Provincial Science and Technology Department [2019FE001 (-058)]; Yunnan Provincial Department of Education [2017zzx201, 2018JS161]; Teaching and Reform Program of Kunming Medical University [2017-JY-Y040]
第一作者机构:[1]Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China.[2]Clinical Medicine, 2015 & 2017 Grade, Kunming Medical University, Kunming, China.
推荐引用方式(GB/T 7714):
Chai Jiagui,Wang Jun,Jiang Rong,et al.Diagnostic Value of Sestrin2 in Patients with Obstructive Sleep Apnea.[J].METABOLIC SYNDROME AND RELATED DISORDERS.2020,18(8):362-367.doi:10.1089/met.2020.0018.
APA:
Chai Jiagui,Wang Jun,Jiang Rong,Wang Haoyan,Zhai Huifen...&Sun Shibo.(2020).Diagnostic Value of Sestrin2 in Patients with Obstructive Sleep Apnea..METABOLIC SYNDROME AND RELATED DISORDERS,18,(8)
MLA:
Chai Jiagui,et al."Diagnostic Value of Sestrin2 in Patients with Obstructive Sleep Apnea.".METABOLIC SYNDROME AND RELATED DISORDERS 18..8(2020):362-367