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Keratin 80 as a diagnostic biomarker with limited prognostic value in non-small cell lung cancer

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收录情况： ◇ SCIE

作者：
Zeng Ying[1] * ; Jiang Hongting[1] * ; Xia Yuting[2,3] ; Wang Zhonglian[1] ; Zhang Fei[1] ; Luo Cha[1] ; Ye Qing[1] ; Jian Wei[1] ; Zhang Jing[1] ; Yang Qingmei[4] ; Fu Qiaofen[1] ;
机构： [1]Department of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China. [2]Departments of Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan, China. [3]West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. [4]Second Department of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
出处：
DOI： 10.1038/s41598-025-04256-1

关键词： KRT80 NSCLC Xuanwei lung cancer Biomarkers

摘要：
To investigate the expression of KRT80 in non-small cell lung cancer (NSCLC) patients and its relationship with clinicopathological factors, prognosis, as well as the differences in KRT80 expression between Xuanwei area and Non-xuanwei area, lung adenocarcinoma and lung squamous cell carcinoma. Based on 178 clinical cases, immunohistochemical methods combined with public databases were used to examine the expression of KRT80 in NSCLC patients and analyze its correlation with various clinicopathological factors and prognosis. The study confirmed the up-regulation of KRT80 expression in NSCLC cancer tissues. Significant regional specific and histological subtype differences in KRT80 expression were revealed. Although the expression level of KRT80 has no direct significant correlation with the prognosis of NSCLC patients, it has a good ability to distinguish cancerous tissue from paracancer tissue. KRT80 can be used as a diagnostic biomarker for NSCLC patients, but its specific mechanism and clinical application value still need to be further explored.© 2025. The Author(s).

基金：
This study was supported by the National Natural Science Foundation of China (No. 82160529), the Joint Fund of the Department of Science and Technology of Yunnan Province (No. 202001 AY070001-141), the Yunnan Revitalization Talent Support Program (grant no. RLQB20220014), and the 535 Talent Project of the First Affiliated Hospital of Kunming Medical University (No. 2023535D17). Kunming Medical University Graduate Student Innovation Fund Project (2024S059).
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外文
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最新[2025]版：
大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
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出版当年[2025]版：
无
最新[2024]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2024版] 最新五年平均 出版当年[2025版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Department of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zeng Ying,Jiang Hongting,Xia Yuting,et al.Keratin 80 as a diagnostic biomarker with limited prognostic value in non-small cell lung cancer[J].Scientific Reports.2025,15(1):19667.doi:10.1038/s41598-025-04256-1.
APA：
Zeng Ying,Jiang Hongting,Xia Yuting,Wang Zhonglian,Zhang Fei...&Fu Qiaofen.(2025).Keratin 80 as a diagnostic biomarker with limited prognostic value in non-small cell lung cancer.Scientific Reports,15,(1)
MLA：
Zeng Ying,et al."Keratin 80 as a diagnostic biomarker with limited prognostic value in non-small cell lung cancer".Scientific Reports 15..1(2025):19667

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