Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests
机构:[1]Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand[2]Department of Hepatology, Third Municipal People's Hospital of Kunming, Kunming 650041, Yunnan Province, China[3]Department of Infectious Diseases, First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China医技科室医学影像中心CT室昆明医科大学附属第一医院[4]Department of Infectious Diseases, Yunnan General Hospital of the Chinese People's Armed Police Forces, Kunming 650111, Yunnan Province, China
AIM: To investigate the peripheral T-lymphocyte subpopulation profile, and its correlations with hepatitis B virus (HBV) replication level in chronic HBV-infected (CHI) individuals with normal liver function tests (LFTs). METHODS: Frequencies of T-lymphocyte subpopulations in peripheral blood were measured by flow cytometry in 216 CHI individuals. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time PCR. Information of age at HBV infection, and maternal HBV infection status was collected. ANOVA linear trend test and linear regression were used in statistical analysis.RESULTS: CHI individuals had significantly decreased relative frequencies of CD+3, CD+4 subpopulations and CD+4/CD+8 ratio, and increased CD+8 subset percentage compared with uninfected individuals (all P<0.001). There was a significant linear relationship between the load of HBV DNA and the parameters of T-lymphocyte subpopulations (ANOVA linear trend test P<0.01). The parameters were also significantly worse among individuals whose mothers were known to be HBV carriers, and those having gained infection before the age of 8 years. In multiple regressions, after adjustment for age at HBV infection and status of maternal HBV infection, log copies of HBV DNA maintained its highly significant predictive coefficient on T-lymphocyte subpopulations, whereas the effect of HBeAg was not significant.CONCLUSION: HBV DNA correlates with modification in the relative T-lymphocyte subpopulation frequencies. High viral load is more powerful than HBeAg in predicting the impaired balance of T-cell subsets.
第一作者机构:[1]Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand[*1]Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
通讯作者:
通讯机构:[*1]Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
推荐引用方式(GB/T 7714):
Jing You,Hutcha Sriplung,Alan Geater,et al.Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests[J].WORLD JOURNAL OF GASTROENTEROLOGY.2008,14(23):3710-3718.doi:10.3748/wjg.14.3710.
APA:
Jing You,Hutcha Sriplung,Alan Geater,Virasakdi Chongsuvivatwong,Lin Zhuang...&Bao-Zhang Tang.(2008).Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests.WORLD JOURNAL OF GASTROENTEROLOGY,14,(23)
MLA:
Jing You,et al."Hepatitis B virus DNA is more powerful than HBeAg in predicting peripheral T-lymphocyte subpopulations in chronic HBV-infected individuals with normal liver function tests".WORLD JOURNAL OF GASTROENTEROLOGY 14..23(2008):3710-3718