Absence of association of the Ala58Val (rs17571) CTSD gene variant with Parkinson's disease or amyotrophic lateral sclerosis in a Han Chinese population
机构：[1]Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China四川大学华西医院[2]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunan Province, 650032, PR China内科科室外科科室神经内科泌尿外科昆明医科大学附属第一医院
Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are neurodegenerative diseases that may share genetic risk factors. The exon variant Aa158Val (rs17571) in CTSD was recently associated with AD, leading us to examine whether it also affects risk of ALS and PD. The rs17571 variant was genotyped using the ligase detection reaction in 569 Han Chinese patients with PD, 301 patients with ALS, and healthy controls age- and gender-matched to each patient group. The frequencies of genotypes and alleles were similar between each disease group and its respective control group. Similar results were obtained when patients were stratified by gender, age at disease onset or type of symptoms at disease onset. These results suggest that the CTSD rs17571 variant may not be associated with risk of ALS or PD in Han Chinese.
基金：
Sichuan Key Project of Science and Technology [2010SZ0086]; Sichuan Province Applied Basic Research Program [2014JY0247]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81471300, 81371281]
第一作者机构：[1]Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, PR China[*2]Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunan Province, 650032, PR China
推荐引用方式(GB/T 7714)：
Xi Jing,Yang Xinglong,Zhao Quanzhen,et al.Absence of association of the Ala58Val (rs17571) CTSD gene variant with Parkinson's disease or amyotrophic lateral sclerosis in a Han Chinese population[J].NEUROSCIENCE LETTERS.2018,662:181-184.doi:10.1016/j.neulet.2017.09.029.
APA：
Xi, Jing,Yang, Xinglong,Zhao, Quanzhen,Zheng, Jinhua,An, Ran...&Xu, Yanming.(2018).Absence of association of the Ala58Val (rs17571) CTSD gene variant with Parkinson's disease or amyotrophic lateral sclerosis in a Han Chinese population.NEUROSCIENCE LETTERS,662,
MLA：
Xi, Jing,et al."Absence of association of the Ala58Val (rs17571) CTSD gene variant with Parkinson's disease or amyotrophic lateral sclerosis in a Han Chinese population".NEUROSCIENCE LETTERS 662.(2018):181-184
