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EphA4 may contribute to microvessel remodeling in the hippocampal CA1 and CA3 areas in a mouse model of temporal lobe epilepsy

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机构： [1]Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008 [2]Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011 [3]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China [4]Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01604, USA

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关键词： ephrin receptor A4 platelet endothelial cell adhesion molecule-1 angiogenesis hippocampus temporal lobe epilepsy pilocarpine

摘要：

Unclustered and pre-clustered ephrin-A5-Fc have identical anti-epileptic effects in the dentate gyrus of hippo campus in a mouse model of temporal lobe epilepsy (TLE), and act through alleviating ephrin receptor A4 (EphA4)-mediated neurogenesis and angiogenesis. However, the effects of ephri n-A5-Fcs on EphA4 and angiogenesis in Cornu Ammonis (CA)1 and CA3 areas remain unclear. In the present study, male C57BL/6 mice underwent pilocarpine-induced TLE. The expression of EphA4 and ephrin-A5 proteins was analyzed by immunohistochemistry, and the mean density and diameter of platelet endothelial cell adhesion molecule-l-labeled microvessels in CA1 and CA3 were calculated in the absence or presence of two types of ephrin-A5-Fc intrahippocampal infusion. Microvessels perpendicular to the pyramidal cell layer decreased; however, microvessels that traversed the layer increased, and became distorted and fragmented. The mean densities and diameters of microvessels gradually increased and remained greater than those in the control group at 56 days post-status epilepticus (SE). The upregulation of EphA4 and ephrin-A5 proteins began at 7 days and was maintained until 28 days, subsequently decreasing slightly at 56 days post-SE. Blockade of EphA4 by unclustered-ephrin-A5-Fc effected a reduction in the mean density and mean diameter of microvessels in the CA1 and CA3 areas; conversely, activation of EphA4 by clustered-ephrin-A5-Fc induced an increase in these values. Ephrin-A5 ligand binding to EphA4 receptor may contribute to angiogenesis during epileptogenesis in the hippocampal CA1 and CA3 areas.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

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出版当年[2017]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

最新[2023]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 ONCOLOGY

影响因子： 3.4 最新[2023版] 3 最新五年平均 1.922 出版当年[2017版] 1.912 出版当年五年平均 1.692 出版前一年[2016版] 1.851 出版后一年[2018版]

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第一作者机构： [1]Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008

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通讯机构： [*1]Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, P.R. China [*2]Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01604, USA

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