OBJECTIVE: The present study was planned to evaluate the long-term effects of elective cardiac resynchronization therapy devices (CRT-D) of coronary heart disease after percutaneous coronary intervention (PCI). PATIENTS AND METHODS: We continuously selected 124 patients with chronic stable heart failure to undergo PCI, and were randomly divided into two groups viz. control group with 72 cases and observation group with 52 cases. The control group was given intensive drugs, while the observation group was treated with a combination of intensive drugs with CRT-D. Followed-up for three years and contrasted their effects. RESULTS: The survival rate of the observation group was significantly higher than that of the control group, and its major adverse cardiac events (MACE) rate was observed to be lower than that of the control group. During the follow- up of the control group, LVEDd, pro-BNP and NYHA increased but LVEF decreased. On the other hand, in the observation group, LVEDd, LVEF, NYHA showed no significant changes, but pro-BNP revealed a significant increase. The physical health, mental health, social health and total score of the observation group were significantly higher than that of the control group. CONCLUSIONS: Patients with chronic stable heart failure who have CRT-D implant testified after PCI could have significant improvement in long-term survival rate, better quality of life, improved cardiac function and reduction in the occurrence of MACE too.