机构:[1]Department of General Surgery,The People's Hospital of Yuxi City, The 6th Affiliated Hospital of KunmingMedical University,Yuxi 653100, China[2]Department of Gastroenterology, The First Affliated Hospital of Kunming Medical University, Kunming650032, China内科科室外科科室消化内科普通外科普通外一科(胃肠与疝外科)昆明医科大学附属第一医院[3]Department of Nephrology, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of KunmingMedical University, Yuxi 653100, China[4]Department of General Surgery, The First Affiliated Hospital of Dali Medical University,Dali 671000, China[5]Department of Pediatrics, The First Affliated Hospital of Kunming Medical University, Kunming 650032,China内科科室儿科昆明医科大学附属第一医院[6]Department of Respiratory, Yan'an Hospital of Kunming City, Kunming 650032, China[7]Department of Orthopedic Surgery, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital ofKunming Medical University, Yuxi 653100,
The association between abdominal obesity (as measured by waist circumference (WC) and waist-to-hip ratio (WHR)) and colorectal cancer (CRC) has not been fully quantified, and the magnitude of CRC risk associated with abdominal obesity is still unclear. A meta-analysis of prospective studies was performed to elucidate the CRC risk associated with abdominal obesity. Pubmed and Embase were searched for studies assessing the association between abdominal obesity and CRC risk. Relative risks (RRs) with 95% confidence intervals (95% CIs) were pooled using random-effects model of meta-analysis. Nineteen prospective cohort studies from eighteen publications were included in this meta-analysis. A total of 12,837 CRC cases were identified among 1,343,560 participants. Greater WC and WHR were significantly associated with increased risk of total colorectal cancer (WC: RR 1.42, 95% CI 1.30, 1.55; WHR: RR 1.39, 95% CI 1.25, 1.53), colon cancer (WC: RR 1.53, 95% CI 1.36, 1.72; WHR: 1.39, 95% CI 1.18, 1.63), and rectal cancer (WC: RR 1.20, 95% CI 1.03, 1.39; WHR: RR 1.22, 95% CI 1.05, 1.42). Subgroup analyses further identified the robustness of the association above. No obvious risk of publication bias was observed. In summary, abdominal obesity may play an important role in the development of CRC.
第一作者机构:[1]Department of General Surgery,The People's Hospital of Yuxi City, The 6th Affiliated Hospital of KunmingMedical University,Yuxi 653100, China
共同第一作者:
通讯作者:
推荐引用方式(GB/T 7714):
Yunlong Dong,Jiao Zhou,Yun Zhu,et al.Abdominal obesity and colorectal cancer risk: systematic review and meta-analysis of prospective studies[J].BIOSCIENCE REPORTS.2017,37:doi:10.1042/BSR20170945.
APA:
Yunlong Dong,Jiao Zhou,Yun Zhu,Tao He,Hong Hu...&Zhaowei Teng.(2017).Abdominal obesity and colorectal cancer risk: systematic review and meta-analysis of prospective studies.BIOSCIENCE REPORTS,37,
MLA:
Yunlong Dong,et al."Abdominal obesity and colorectal cancer risk: systematic review and meta-analysis of prospective studies".BIOSCIENCE REPORTS 37.(2017)