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Mitochondrial D310 instability in Chinese lung cancer patients

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收录情况： ◇ SCIE

作者：

机构： [1]Department of ICU, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China, [2]Department of Anesthesiology, the firstaffiliated hospital of Kunming Medical University, Kunming, Yunnan Province, China, [3]Department of Clinical Laboratory, Shanxi Tumor Hospital,Taiyuan, Shanxi, China, [4]Department of Medical Service, Unit 65176 of PLA, Dalian, Liaoning, China, [5]Department of Cardiology and ClinicalLaboratory, 211 Hospital of PLA, Harbin, Heilongjiang, China

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关键词： Chinese D310 mutation lung cancer mitochondrial DNA

摘要：

To characterize the somatic mutation spectrum of mitochondrial DNA at D310 in Chinese lung cancer patients and evaluate its potential significance in Chinese lung cancer diagnosis, in this study, 237 samples, including lung tumor, adjacent normal tissue and blood samples of 79 lung cancer patients were analyzed. By comparing sequences of D310 between lung cancer tissues, adjacent normal tissue and blood samples, the somatic mutations at D310 were detected in 17.72% (14/79) of Chinese lung cancer patients; this implied that somatic mutations at D310 could be served as valuable biomarker for diagnostic of Chinese lung cancer. Further analyses indicated that deletion and heterogeneity were the predominant characters for somatic mutations detected at D310 of Chinese lung cancer patients.

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中科院(CAS)分区：

出版当年[2017]版：

大类 | 3 区生物

小类 | 4 区遗传学

最新[2023]版：

无

JCR分区：

出版当年[2016]版：

Q4 GENETICS & HEREDITY

最新[2023]版：

Q4 GENETICS & HEREDITY

影响因子： 1.1 最新[2023版] 1.3 最新五年平均 0 出版当年[2016版] 0 出版当年五年平均 0 出版前一年[2015版] 0.575 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of ICU, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China,

通讯作者：

通讯机构： [*1]Department of ICU, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China

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