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Steroidal saponins with cytotoxic activity from the rhizomes of Paris polyphylla var. yunnanensis

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收录情况： ◇ SCIE

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机构： [a]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [b]College of Forestry, Southwest Forestry University, Kunming 650224, China [c]Department of Pharmacology, School of Medicine, Yale University, New Haven, CT, USA [d]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

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关键词： Paris polyphylla var yunnanensis Steroidal saponins Dianchonglouoside A Dianchonglouoside B Cytotoxic activity

摘要：

Two previously unreported spirostanol saponins, dianchonglouosides A and B (1 and 2), along with 7 known steroidal saponins (3-9) were isolated from the rhizomes of Paris polyphylla var. yunnanensis. Their structures were elucidated by extensive spectroscopic analysis (MS, 1D, and 2D NMR), and chemical methods. The cytotoxic activities of the isolated compounds 1-9 were also evaluated against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 7 had the strongest cytotoxic activity against the two cancer cell lines with the IC50 values of 0.6 and 0.9 mM, respectively. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

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出版当年[2016]版：

大类 | 4 区生物

小类 | 4 区生化与分子生物学 4 区植物科学

最新[2023]版：

大类 | 4 区生物学

小类 | 4 区药物化学 4 区植物科学

JCR分区：

出版当年[2015]版：

Q2 PLANT SCIENCES Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 PLANT SCIENCES Q4 CHEMISTRY, MEDICINAL

影响因子： 1.3 最新[2023版] 1.4 最新五年平均 1.353 出版当年[2015版] 1.451 出版当年五年平均 1.45 出版前一年[2014版] 1.418 出版后一年[2016版]

第一作者：

第一作者机构： [a]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [b]College of Forestry, Southwest Forestry University, Kunming 650224, China

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