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Steroidal saponins with induced platelet aggregation activity from the aerial parts of Paris verticillata

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收录情况： ◇ SCIE

作者：

机构： [a]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [b]College of Forestry, Southwest Forestry University, Kunming 650224, China [c]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

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关键词： Paris verticillata Liliaceae Steroidal saponins Parisverticosides A-D Induced platelet aggregation activity

摘要：

In order to utilize and protect the resources of Rhizoma Paridis rationally, we carried out a phytochemical investigation on the non-medicinal (aerial) parts of Paris verticillata that led to the isolation of fifteen steroidal saponins. Among them, three are new spirostanol saponins, named parisverticosides A-C (1-3), as well as one new cholestane glycoside, named parisverticoside D (4). Their structures were elucidated by extensive spectroscopic analysis and acid hydrolysis. The aglycone of compound 1 is a new spirostane and identified as (23S,24S,25S)-spirost-5-en-1 beta,3 beta,23, 24-tetraol. The selected isolates were evaluated for induced platelet aggregation activity and compound 5 showed 62% maximal platelet aggregation rate at the concentration of 300 mu g/mL. (C) 2014 Elsevier Inc. All rights reserved.

基金：

基金编号： KSZD-EW-Z-004-03-4 31170333 IRT13067 XBKM-2011-004

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出版当年[2015]版：

大类 | 3 区医学

小类 | 4 区生化与分子生物学 4 区内分泌学与代谢

最新[2023]版：

大类 | 4 区医学

小类 | 3 区生化与分子生物学 4 区内分泌学与代谢

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出版当年[2014]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q3 ENDOCRINOLOGY & METABOLISM Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 2.1 最新[2023版] 2.4 最新五年平均 2.639 出版当年[2014版] 2.696 出版当年五年平均 2.716 出版前一年[2013版] 2.513 出版后一年[2015版]

第一作者：

第一作者机构： [a]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [b]College of Forestry, Southwest Forestry University, Kunming 650224, China

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