机构：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China[2]University of Chinese Academy of Sciences, Beijing 100049, China[3]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China内科科室皮肤科昆明医科大学附属第一医院
Eight new spirostane glycosides, taccaosides E-L (2-7, 11, and 14), along with 7 known spirostane glycosides were isolated from the extract of the whole plants of Tacca plantaginea (Hance) Drenth. Their structures were established on the basis of physical data, spectroscopic analysis (MS, 1D and 2D NMR), and chemical methods. The cytotoxicities of the isolates were evaluated in vitro against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 1 had the strongest cytotoxic activity with IC50 values of 1.7 mu M and 1.2 mu M against the two cancer cell lines, respectively. Furthermore, the spirostane glycosides with 17 alpha-hydroxyl group at their aglycones (10, 12, and 15) were tested for the induced platelet aggregation activity. (C) 2015 Elsevier Inc. All rights reserved.
基金：
National Natural Science Funding of ChinaNational Natural Science Foundation of China [31170333, 31570363]; Key Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [KSZD-EW-Z-004-03-4]; Innovation Team of the Ministry of Education [IRT13067]; Scientific and Technological Projects of Yunnan Province [2014113008]; Natural Science Foundation of Yunnan ProvinceNatural Science Foundation of Yunnan Province [2015FA031]
第一作者机构：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China[2]University of Chinese Academy of Sciences, Beijing 100049, China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Zhen-Hua,Yan Huan,Si Yong-Ai,et al.Bioactive spirostane glycosides from Tacca plantaginea[J].STEROIDS.2016,106:86-92.doi:10.1016/j.steroids.2015.12.013.
