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MicroRNA-584 functions as a tumor suppressor and targets PTTG1IP in glioma

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Yunnan 650032, China [2]Institute of Neuroscience, Kunming Medical University, Yunnan 650050, China

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关键词： Glioma microRNA miR-584 PTTG1IP

摘要：

MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression at the post transcriptional level. Compelling evidence shows that there are causative links between miRNAs deregulation and cancer development and progression. In this study, we demonstrated that miR-584 was downregulated in human glioma and could suppress growth of the human glioma cell line U87-MG and U251-MG. Bioinformatics analysis indicated that PTTG1IP was a putative target of miR-584. In a Luciferase reporter system, we confirmed that PTTG1IP was a direct target gene of miR-584. These findings indicate that miR-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR-584 has a tumor suppressive role in human glioma pathogenesis.

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中科院(CAS)分区：

出版当年[2015]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区病理学

最新[2023]版：

无

JCR分区：

出版当年[2014]版：

Q3 PATHOLOGY Q3 ONCOLOGY

最新[2023]版：

Q4 ONCOLOGY Q4 PATHOLOGY

影响因子： 1.1 最新[2023版] 1.3 最新五年平均 1.891 出版当年[2014版] 2.001 出版当年五年平均 1.783 出版前一年[2013版] 1.581 出版后一年[2015版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Yunnan 650032, China

通讯作者：

通讯机构： [1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Yunnan 650032, China [*1]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Yunnan 650032, China.

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