机构：[a]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Yunnan, 650032, China外科科室神经外科神经外一科（神经外科）昆明医科大学附属第一医院[b]Institute of Neuroscience, Kunming Medical University, Yunnan, 650050, China
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression at the post transcriptional level. Compelling evidence shows that there are causative links between miRNAs deregulation and cancer development and progression. In this study, we demonstrated that miR-584 was downregulated in human glioma and could suppress growth of the human glioma cell line U87-MG and U251-MG. Bioinformatics analysis indicated that PTTG1IP was a putative target of miR-584. In a Luciferase reporter system, we confirmed that PTTG1IP was a direct target gene of miR-584. These findings indicate that miR-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR-584 has a tumor suppressive role in human glioma pathogenesis.
语种：
外文
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区肿瘤学4 区病理学
最新[2023]版：
无
第一作者：
第一作者机构：[a]Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Yunnan, 650032, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang X.-P,Deng X.-L,Li L.-Y.MicroRNA-584 functions as a tumor suppressor and targets PTTG1IP in glioma[J].International Journal of Clinical and Experimental Pathology.2014,7(12):
APA：
Wang, X.-P,Deng, X.-L&Li, L.-Y.(2014).MicroRNA-584 functions as a tumor suppressor and targets PTTG1IP in glioma.International Journal of Clinical and Experimental Pathology,7,(12)
MLA：
Wang, X.-P,et al."MicroRNA-584 functions as a tumor suppressor and targets PTTG1IP in glioma".International Journal of Clinical and Experimental Pathology 7..12(2014)
