机构:[1]Department of Ophthalmology, General Hospital of GuangzhouMilitary Command of PLA, 111 Liuhua Road, Guangzhou, 510010,China[2]State Key Laboratory of Ophthalmology, Zhongshan OphthalmicCenter, Sun Yat-sen University, Guangzhou, 510275, China[3]Department of Ophthalmology, The First Affiliated Hospital ofKunming Medical College, Kunming, 650031, China外科科室眼科昆明医科大学附属第一医院
Proliferative vitreoretinopathy (PVR), the most common cause of failure of rhegmatogenous retinal detachment (RD) surgery, is an anomalous scarring process related to ocular inflammation. Lysyl oxidase (LOX) is a copper-dependent amine oxidase that may play important roles in ocular tissue integrity. The aim of this study was to investigate whether polymorphisms in the LOX gene were associated with susceptibility to RD and PVR. We screened the promoter region of LOX gene and tested two previously reported polymorphisms (-22 G/C and 473 G/A) in RD patients with or without PVR and healthy controls. Data showed that prevalence of the -22CC genotype and -22C allele were significantly higher in the RD cases than in the control group after adjustment for sex and age (p < 0.001 and p < 0.001, respectively). Similarly, a significant difference was observed regarding LOX 473GA genotype and 473A allele between RD patients and healthy donors after adjustment for sex and age (p = 0.005 and p = 0.012, respectively). Also, when compared to RD cases without PVR, patients who developed PVR had significantly higher numbers of -22CC genotype and -22C allele (p = 0.048 and p = 0.003, respectively). These results indicated that LOX polymorphisms were associated with increased susceptibility to RD and PVR and suggest a potential correlation between LOX and ocular inflammation.
基金:
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China [2011KF03]
第一作者机构:[1]Department of Ophthalmology, General Hospital of GuangzhouMilitary Command of PLA, 111 Liuhua Road, Guangzhou, 510010,China
共同第一作者:
通讯作者:
通讯机构:[*1]Department of Ophthalmology, General Hospital of Guangzhou Military Command of PLA, 111 Liuhua Road, Guangzhou, 510010, China
推荐引用方式(GB/T 7714):
Yu Honghua,Li Tao,Zou Xiulan,et al.Effects of Lysyl Oxidase Genetic Variants on the Susceptibility to Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy[J].INFLAMMATION.2013,36(4):839-844.doi:10.1007/s10753-013-9610-6.
APA:
Yu, Honghua,Li, Tao,Zou, Xiulan,Yuan, Ling,Hu, Jie...&Zou, Yuping.(2013).Effects of Lysyl Oxidase Genetic Variants on the Susceptibility to Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy.INFLAMMATION,36,(4)
MLA:
Yu, Honghua,et al."Effects of Lysyl Oxidase Genetic Variants on the Susceptibility to Rhegmatogenous Retinal Detachment and Proliferative Vitreoretinopathy".INFLAMMATION 36..4(2013):839-844