机构：[a]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College, #295 Xichang Road, Kunming, Yunnan, 650031, China内科科室精神科昆明医科大学附属第一医院[b]School of Life Sciences, Yunnan University, #2 North Cuihu Road, Kunming, Yunnan, 650031, China昆明医科大学附属第一医院云南省第一人民医院[c]Clinical Psychology Department, Weihai Jingqu Hospital. #122 Qilu Road, Weihai, Shandong, 264200, China[d]Clinical Psychology Department, HELP Institute Malaysia
Development of reliable diagnostic bio-markers for schizophrenia remains a diagnostic challenge. Serum NGF and IL-2 were analyzed to examine the diagnostic efficiency and predictive capability of these two biomarkers in relation to schizophrenia diagnosis. Thirty neuroleptic naive subjects with first-episode schizophrenia. thirty patients with major depressive disorder (MDD) and twenty-eight healthy control subjects participated in the study. One-way ANOVA demonstrated significantly lower serum IL-2 and NGF among schizophrenic patients and patients with MDD compared with healthy controls. Receiver operating characteristic (ROC) curve analysis was used to ascertain diagnostic efficiency of serum IL-2 and NGF levels. Area under the ROC curve (AUC) revealed a high level of differentiation between schizophrenic patients and healthy controls for both IL-2 and NGF serum concentrations. Diagnostic efficiency of combined NGF and IL-2 serum levels was also high in schizophrenic patients compared with healthy controls. Serum NGF and IL-2 are promising as potential screening or diagnostic biomarkers for schizophrenia and may be a useful adjunct for clinical assessment. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
基金：
This study was supported by the
National Natural Science Foundation of China (Grant No. 2004C0018R).
第一作者机构：[a]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College, #295 Xichang Road, Kunming, Yunnan, 650031, China[b]School of Life Sciences, Yunnan University, #2 North Cuihu Road, Kunming, Yunnan, 650031, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Peng Xiong,Yong Zeng,Jing Wan,et al.The role of NGF and IL-2 serum level in assisting the diagnosis in first episode schizophrenia[J].PSYCHIATRY RESEARCH.2011,189(1):72-76.doi:10.1016/j.psychres.2010.12.017.
APA：
Peng Xiong,Yong Zeng,Jing Wan,Diana Huang XiaoHan,Deyong Tan...&Mingxing Ma.(2011).The role of NGF and IL-2 serum level in assisting the diagnosis in first episode schizophrenia.PSYCHIATRY RESEARCH,189,(1)
MLA：
Peng Xiong,et al."The role of NGF and IL-2 serum level in assisting the diagnosis in first episode schizophrenia".PSYCHIATRY RESEARCH 189..1(2011):72-76
