机构:[1]Department of Neurology,West China Hospital, Sichuan University, Sichuan Province, P R China四川大学华西医院[2]Key Laboratory of Human Disease Biotherapy of the State and Ministry of Education,West China Hospital, Sichuan University, Sichuan Province, P R China四川大学华西医院[3]Department of Neurology,the First Affiliated Hospital of Kunming Medical College, Kunming City, Yunnan Province, P R China内科科室神经内科昆明医科大学附属第一医院云南省第一人民医院[4]Department of Neurology,Hua Shan Hospital, FuDan University, Shanghai, P R China.
Background: Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life, and has a greater mortality risk than Alzheimer's disease among the elderly population group. The angiotensin-converting enzyme insertion/deletion polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remain inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effect of the insertion/deletion polymorphism on the vascular dementia. Methods: We applied a random-effects model or fixed-effects model to combine odds ratio and 95% confidence intervals. Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias. Results: A total of 10 studies were included worldwide. Publication bias was not observed. There was no evidence of the association of angiotensin-converting enzyme insertion/deletion polymorphism with the vascular dementia in general or in the Asian populations or in the Caucasian populations. Conclusions: The angiotensin-converting enzyme insertion/deletion polymorphism might be neutral to vascular dementia.
第一作者机构:[3]Department of Neurology,the First Affiliated Hospital of Kunming Medical College, Kunming City, Yunnan Province, P R China
通讯作者:
通讯机构:[*1]Department of Neurology, West China Hospital, Sichuan University, No 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, P R China
推荐引用方式(GB/T 7714):
Liu Hua,Liu Ming,Li Wei,et al.Association of ACE I/D Gene Polymorphism With Vascular Dementia: A Meta-Analysis[J].JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY.2009,22(1):10-22.doi:10.1177/0891988708328221.
APA:
Liu, Hua,Liu, Ming,Li, Wei,Wu, Bo,Zhang, Shi-hong...&Wang, Yi.(2009).Association of ACE I/D Gene Polymorphism With Vascular Dementia: A Meta-Analysis.JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,22,(1)
MLA:
Liu, Hua,et al."Association of ACE I/D Gene Polymorphism With Vascular Dementia: A Meta-Analysis".JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY 22..1(2009):10-22