Background and Purpose: Silent brain infarct (SBI), which has traditionally been considered clinically silent, has been proposed as a subclinical risk marker for future cognitive function decline. Methods: We conducted a systematic review of literature in the Cochrane Library, MEDLINE, EMBASE, and the China National Knowledge Infrastructure database. Results: In the end, 19 case-control studies, comprising 6712 participants, and 3 prospective cohort studies comprising 4433 participants, met all inclusion criteria and were included in the systematic review. Meta-analysis of 9 studies showed that SBI was an important factor in cognitive function decline (Mini-Mental State score) (standardized mean difference -.47, 95% confidence interval; -.72 to -.22). Another meta-analysis of 4 studies reported the SBI was an independent factor in cognitive dysfunction (Montreal Cognitive Assessment Scale) (standardized mean difference -3.36, 95% confidence interval; -5.90 to -.82). Ten studies further reported that SBI was associated with decreases in specific areas of cognitive function. Conclusions: These results suggest that rather than being clinically silent, SBI might be a factor inducing cognitive dysfunction.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81701173]; Joint fund project of applied basic research of Kunming Medical University [2018FE001(-141)]
第一作者机构:[1]Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, PR China.
通讯作者:
通讯机构:[*1]Department of Neurology, First Affiliated Hospital of Kunming Medical University, No. 295 Xi Chang Lu, Kunming 650032, Yunnan Province, PR China.
推荐引用方式(GB/T 7714):
Lei Chunyan,Deng Qionghua,Li Haijiang,et al.Association Between Silent Brain Infarcts and Cognitive Function: A Systematic Review and Meta-Analysis[J].JOURNAL OF STROKE & CEREBROVASCULAR DISEASES.2019,28(9):2376-2387.doi:10.1016/j.jstrokecerebrovasdis.2019.03.036.
APA:
Lei, Chunyan,Deng, Qionghua,Li, Haijiang&Zhong, Lianmei.(2019).Association Between Silent Brain Infarcts and Cognitive Function: A Systematic Review and Meta-Analysis.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,28,(9)
MLA:
Lei, Chunyan,et al."Association Between Silent Brain Infarcts and Cognitive Function: A Systematic Review and Meta-Analysis".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 28..9(2019):2376-2387