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Research Progress on Pathogenic Genes of Ph-like Acute Lymphoblastic Leukemia--Review

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收录情况： ◇ 统计源期刊 ◇ 北大核心 ◇ CSCD-C

作者：
Li, Z.-Z[a] ; Wang, Y.-J[a] ; Feng, J.-K[a] ; Tan, J.-B[a] ; Zhao, R.-B[a] ; Yang, T.-H[b] ;
机构： [a]Medical College of Kunming University of Science and Technology, Kunming 650032,Yunnan Province, China;Department of Hematology, The First People's Hospital Affiliated to Kunming University of Science and Technology, Kunming 650032 Yunnan Province, China;Clinical Medical Center for Blood Diseases in Yunan Kunming 650032 Yunnan Province, China;Hematology and Blood Diseases Hospital Yunnan, Kunming 650032, Yunnan Province, China [b]Medical College of Kunming University of Science and Technology, Kunming 650032,Yunnan Province, China;Department of Hematology, The First People's Hospital Affiliated to Kunming University of Science and Technology, Kunming 650032 Yunnan Province, China;Clinical Medical Center for Blood Diseases in Yunan Kunming 650032 Yunnan Province, China;Hematology and Blood Diseases Hospital Yunnan, Kunming 650032, Yunnan Province, China,E-mail:
出处：
DOI： 10.19746/j.cnki.issn.1009-2137.2020.02.057
ISSN：

摘要：
题目: Ph-like急性淋巴细胞白血病致病基因的研究进展. 摘要: 费城染色体样急性淋巴细胞白血病（Philadelphia chromosome-like acute lymphoblastic leukemia，Ph-like ALL或BCR-ABL1-like ALL）是指基因表达谱与Ph阳性ALL相似，但缺乏BCR-ABL1融合的一类急性白血病。Ph-like ALL涉及多种基因组，激活激酶和细胞因子受体信号的改变。本文将针对近几年Ph-like ALL在JAK-STAT通路异常激活，ABL激酶通路基因异常，TKI在Ph-like ALL中的抗性，SH2B3基因的失活性突变，IKZF1基因异常的研究进展作一总结。并就新型致病基因（ATF7IP外显子9和PDGFRB外显子11之间的融合，PDGFRB外显子11-23与AGGF1基因外显子1-6融合造成的PDGFRBC843G突变等）的前沿最新进展作一综述.

基金编号： 81700164 2018FB112 2019LCZXKF-XY02，2019LLZXKFXY11 2018FE001(-156 H2017012

语种：
中文
PubmedID：
第一作者：
第一作者机构： [a]Medical College of Kunming University of Science and Technology, Kunming 650032,Yunnan Province, China;Department of Hematology, The First People's Hospital Affiliated to Kunming University of Science and Technology, Kunming 650032 Yunnan Province, China;Clinical Medical Center for Blood Diseases in Yunan Kunming 650032 Yunnan Province, China;Hematology and Blood Diseases Hospital Yunnan, Kunming 650032, Yunnan Province, China
推荐引用方式(GB/T 7714)：
Li Z.-Z,Wang Y.-J,Feng J.-K,等.Research Progress on Pathogenic Genes of Ph-like Acute Lymphoblastic Leukemia--Review[J].Zhongguo shi yan xue ye xue za zhi.2020,28(2):695-699.

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