Predictive Value of Postoperative Peripheral CD4+T Cells Percentage in Stage I-III Colorectal Cancer: A Retrospective Multicenter Cohort Study of 1028 Subjects
Objective: Association of postoperative peripheral CD4+ T cells percentage and recurrence in colorectal cancer (CRC) remains to be explored. Therefore, we aimed to investigate the association between the postoperative peripheral CD4+ T cells percentage and recurrence in CRC patients. Patients and Methods: Consecutive stage I-III CRC patients without neoadjuvant treatment undergoing curative resection from January 2010 to July 2016 were identified in two Chinese centers. The association between the postoperative CD4+ T cells percentage, measured within 12 weeks after surgery, and recurrence-free survival (RFS) was analyzed. Results: A total of 1028 patients were identified (training set: 913 patients, validation set: 115 patients). In the training set, the 5-year RFS rate of the 441 patients with abnormal postoperative CD4+ T cells percentage was significantly lower than that of those with normal percentage (70.3% [95% CI 65.7-75.2%] vs 77.6% [95% CI 73.7-81.7%] and unadjusted hazard ratio [HR] 1.36 [95% CI 1.04-1.78], P=0.02). The result was confirmed in the validation set. Multivariable Cox regression analysis demonstrated that the association of postoperative CD4+ T cells percentage with 5-year RFS was independent both in the training and validation sets. In propensity score matching analysis, patients with normal postoperative CD4+ T cells percentage were found to have a favourable response to adjuvant chemotherapy (HR 0.29 [95% CI 0.12-0.72], P=0.008). Conclusion: Postoperative peripheral CD4+ T cells percentage is a predictive biomarker for RFS in patients with CRC, which can identify those who will benefit from adjuvant chemotherapy.
基金:
Applied Basic Research Projects of Yunnan Province, China [2018FE001-065, 2018FE001-251]
第一作者机构:[1]Kunming Med Univ, Dept Radiol, Affiliated Hosp 3, Yunnan Canc Hosp,Yunnan Canc Ctr, Kunming 650118, Yunnan, Peoples R China
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推荐引用方式(GB/T 7714):
Li Zhenhui,Li Shaoyou,Liang Yun,et al.Predictive Value of Postoperative Peripheral CD4+T Cells Percentage in Stage I-III Colorectal Cancer: A Retrospective Multicenter Cohort Study of 1028 Subjects[J].CANCER MANAGEMENT AND RESEARCH.2020,12:5505-5513.doi:10.2147/CMAR.S259464.
APA:
Li, Zhenhui,Li, Shaoyou,Liang, Yun,Pu, Hongjiang,Tu, Changling...&You, Dingyun.(2020).Predictive Value of Postoperative Peripheral CD4+T Cells Percentage in Stage I-III Colorectal Cancer: A Retrospective Multicenter Cohort Study of 1028 Subjects.CANCER MANAGEMENT AND RESEARCH,12,
MLA:
Li, Zhenhui,et al."Predictive Value of Postoperative Peripheral CD4+T Cells Percentage in Stage I-III Colorectal Cancer: A Retrospective Multicenter Cohort Study of 1028 Subjects".CANCER MANAGEMENT AND RESEARCH 12.(2020):5505-5513