Rhotomentodiones C-E, three new polymethylated phloroglucinol meroterpenoids with diverse configurations, were isolated from the twigs and leaves ofRhodomyrtus tomentosa. Their structures and absolute configurations were established mainly by means of comprehensive spectroscopic data and electron circular dichroism (ECD) calculation. Among them, Rhotomentodione D (2) exhibited both antibacterial activity with an MIC value of 12.5 mu g/mL againstPropionibacterium acnesand AChE inhibitory activity with an IC(50)value of 22.9 mu m.
基金:
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31970377]; Yunnan Science Foundation for Excellent Young Scholars; Youth Innovation Promotion Association CAS [2019381]; Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents; Major Biomedical Project of Yunnan Province [2018ZF005, 2019ZF010]; Innovation Team of the Ministry of Education [IRT-17R49]; State Key Laboratory of Phytochemistry and Plant Resources in West China [P2019-ZZ02]; Top Young Talent of the Ten Thousand Talents Program of Yunnan Province