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Structurally Diverse Polymethylated Phloroglucinol Meroterpenoids from Baeckea frutescens

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机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Medicinal Chemistry, Kunming 650201, China [2]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [3]Kunming Botanee Bio-Technique Co. Ltd, Kunming 650106, China

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关键词： Baeckea frutescens Myrtaceae Polymethylated phloroglucinol meroterpenoids Anti-inflammatory activity

摘要：

Phytochemical investigation of the MeOH extract of twigs and leaves of Baeckea frutescens led to the isolation of seven new polymethylated phloroglucinol meroterpenoids (PPMs), named baeckfrutones M-S (1-7). Their structures and absolute configurations were determined by spectroscopic analyses, chiral-phase HPLC analysis, and electronic circular dichroism (ECD) calculations. PPM 1 is a novel meroterpenoid possessing a 6/6/5/3 tetracyclic skeleton in PPMs, whereas 3 and 4 are the first hydroxytasmanone type phloroglucinol-monoterpene hybrids. (+)-2 and 7 displayed potent antiinflammatory activity with IC50 values of 20.86 +/- 0.60 and 36.21 +/- 1.18 mu M, respectively.

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出版当年[2019]版：

大类 | 4 区化学

小类 | 4 区药物化学

最新[2023]版：

大类 | 3 区化学

小类 | 3 区药物化学

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无

最新[2023]版：

Q1 CHEMISTRY, MEDICINAL

影响因子： 4.8 最新[2023版] 3.9 最新五年平均 0 出版当年[2018版] 0 出版当年五年平均 0 出版前一年[2017版]

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第一作者机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Medicinal Chemistry, Kunming 650201, China

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