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Sesquiterpenes from Chloranthus holostegius with anti-inflammatory activities

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收录情况： ◇ SCIE

作者：
Yan Huan[1,2,3,6] * ; Xu Li-Li[1,2] * ; Zheng Xue-Fang[1,2] * ; Zou Xin-Feng[1,2] ; Xiao Long-Gao[1,2,3] ; Zhou Yong-Sheng[1,2,3] ; He Li[4,5] ; Liu Hai-Yang[1,2] ;
机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [2]Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China [3]University of Chinese Academy of Sciences, Beijing 100039, China [4]Skin Health Research Center, Yunnan Characteristic Plant Extraction Laboratory, Kunming 650000, China [5]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China [6]Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Centre for Invasion Biology, Institute of Biodiversity, School of Ecology and Environmental Science, Yunnan University, Kunming 650500, China
出处：
DOI： 10.1016/j.fitote.2023.105766
ISSN：

关键词： Chloranthus holostegius Sesquiterpenes Chloranholosins A–M Anti-inflammatory activity

摘要：
The phytoconstituents of the whole plants of Chloranthus holostegius were investigated. As a result, thirteen undescribed sesquiterpenes (chloranholosins A-M, 1-13), including ten acorane-type sesquiterpenes (1-10), one germacrene-type sesquiterpene (11), and two lindenane-type sesquiterpenes (12-13), together with fifteen known sesquiterpenes were isolated. Their structures and absolute configurations were elucidated by a comprehensive method including the spectroscopic data, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction. Chloranholosin L (12) was elucidated as a rare lindenane-type sesquiterpene featuring 14α-Me and 5-OH moieties. And chloranholosin M (13) was the first lindenane-type sesquiterpene possessing β-cyclopropane, 14α-Me, and 5β-H configuration from the family Chloranthaceae. Furthermore, twelve new isolates and some known sesquiterpenes were evaluated for their inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophage cells. Among them, compounds 12, 16, and 23 showed comparable inhibitory activity to that of the positive control, with IC50 values of 47.9, 41.5, and 48.3 μM, respectively.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This work was financially supported by the National Natural Science Foundation of China (32000280), Yunnan Revitalization Talent Support Program “Top Team” Project (202305AT350001), the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents (YNWR-CYJS-2019-011), the Science and Technology Project of Yunnan Province (202201AT070149), the Training of Technological Innovation Talents of Yunnan Province (202305AD160009), and the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001).
语种：
外文
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出版当年[2025]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 药物化学 3 区 药学
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出版当年[2024]版：
无
最新[2023]版：
Q3 CHEMISTRY, MEDICINAL Q3 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2023版]

第一作者：
第一作者机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [2]Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China [3]University of Chinese Academy of Sciences, Beijing 100039, China [6]Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Centre for Invasion Biology, Institute of Biodiversity, School of Ecology and Environmental Science, Yunnan University, Kunming 650500, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [2]Yunnan Characteristic Plant Extraction Laboratory, Kunming 650106, China
推荐引用方式(GB/T 7714)：
Yan Huan,Xu Li-Li,Zheng Xue-Fang,et al.Sesquiterpenes from Chloranthus holostegius with anti-inflammatory activities[J].FITOTERAPIA.2024,172:doi:10.1016/j.fitote.2023.105766.
APA：
Yan Huan,Xu Li-Li,Zheng Xue-Fang,Zou Xin-Feng,Xiao Long-Gao...&Liu Hai-Yang.(2024).Sesquiterpenes from Chloranthus holostegius with anti-inflammatory activities.FITOTERAPIA,172,
MLA：
Yan Huan,et al."Sesquiterpenes from Chloranthus holostegius with anti-inflammatory activities".FITOTERAPIA 172.(2024)

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