机构：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China[2]Yunnan University of Traditional Chinese Medicine, Kunming 650500, China[3]Institute of Medicinal Chemistry and Chemical Biology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China[4]Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China内科科室皮肤科昆明医科大学附属第一医院[5]Kunming Botanee Bio-Technique Co. Ltd., Kunming 650106, China
Twelve new polymethylated phloroglucinol meroterpenoids (PPMs), baeckfrutones A-L (1-12), were isolated from the twigs and leaves of Baeckea frutescens. Their structures and absolute configurations were unambiguously established by extensive spectroscopic methods (HRESIMS, NMR, and ECD) and single crystal X-ray diffraction. PPM 1 is a rare PPM comprising enone-type phloroglucinol and alpha-phellandrene units, whereas 2-4, 6, and 7, are the first hybrids of enone-type phloroglucinol and sabinene moieties with different stereochemistry. (-)-2 and 11 showed remarkable cytotoxicities against DU145 and HCT116 cells with IC50 values of 1.33 and 12.89 mu M, respectively. 6, 7, (+)-9, and 10 displayed significant anti-inflammatory activity with inhibitory rates of 74.64, 75.37, 55.13, and 75.01% at the concentration of 50 mu M, respectively. (C) 2018 Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31570363, 31770391]; Key Research and Development Plan of Yunnan Province-Special Project of Science and Technology in Yunnan Province [2017IB007]; Major Bio-Medical Project of Yunnan Province [2017AB001, 2018ZF005]; Scientific and Technological Projects of Yunnan Province [2017FB128]; Innovation Team of the Ministry of Education [IRT-17R49]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2017-ZZ04, P2017-KF06]; Kunming Institute of Botany, Chinese Academy of SciencesChinese Academy of Sciences
第一作者机构：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China
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推荐引用方式(GB/T 7714)：
Qin Xu-Jie,Zhi Yin-E.,Yan Huan,et al.Baeckfrutones A-L, polymethylated phloroglucinol meroterpenoids from the twigs and leaves of Baeckea frutescens[J].TETRAHEDRON.2018,74(46):6658-6666.doi:10.1016/j.tet.2018.09.050.
APA：
Qin, Xu-Jie,Zhi, Yin-E.,Yan, Huan,Zhang, Yu,Liu, Hui...&Liu, Hai-Yang.(2018).Baeckfrutones A-L, polymethylated phloroglucinol meroterpenoids from the twigs and leaves of Baeckea frutescens.TETRAHEDRON,74,(46)
MLA：
Qin, Xu-Jie,et al."Baeckfrutones A-L, polymethylated phloroglucinol meroterpenoids from the twigs and leaves of Baeckea frutescens".TETRAHEDRON 74..46(2018):6658-6666
