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Related Effects of Methamphetamine on the Intestinal Barrier via Cytokines, and Potential Mechanisms by Which Methamphetamine May Occur on the Brain-Gut Axis.

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收录情况： ◇ SCIE ◇ 预警期刊

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机构： [1]Department of Intestine and Hernia Surgery,The First Affiliated Hospital of Kunming Medical University,Kunming,China, [2]NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, China, [3]Yunnan Institute of Digestive Disease,The First Affiliated Hospital of Kunming Medical University,Kunming,China

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关键词： methamphetamine intestinal barrier tight junction (TJ) cytokines the brain-gut axis

摘要：

Methamphetamine (METH) is an illegal drug widely abused in many countries. Methamphetamine abuse is a major health and social problem all over the world. However, the effects of METH on the digestive system have rarely been reported. Previous studies and clinical cases have shown that METH use can lead to the impaired intestinal barrier function and severe digestive diseases. METH can cause multiple organ dysfunction, especially in the central nervous system (CNS). The gut microbiota are involved in the development of various CNS-related diseases via the gut-brain axis (GBA). Here, we describe the related effects of METH on the intestinal barrier via cytokines and the underlying mechanisms by which METH may occur in the brain-gut axis.Copyright © 2022 Li, Kong, Bi and Luo.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区医学：内科

最新[2023]版：

大类 | 3 区医学

小类 | 3 区医学：内科

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出版当年[2022]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 3.1 最新[2023版] 3.4 最新五年平均 3.9 出版当年[2022版] 4.2 出版当年五年平均 5.058 出版前一年[2021版] 3.1 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Intestine and Hernia Surgery,The First Affiliated Hospital of Kunming Medical University,Kunming,China, [2]NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, China,

通讯作者：

通讯机构： [1]Department of Intestine and Hernia Surgery,The First Affiliated Hospital of Kunming Medical University,Kunming,China, [2]NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, China, [3]Yunnan Institute of Digestive Disease,The First Affiliated Hospital of Kunming Medical University,Kunming,China

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Related Effects of Methamphetamine on the Intestinal Barrier via Cytokines, and Potential Mechanisms by Which Methamphetamine May Occur on the Brain-Gut Axis.

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