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The Association Between Plasma Copper Concentration and Prevalence of Diabetes in Chinese Adults With Hypertension.

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机构: [1]School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China, [2]Department of Disease Control and Prevention, Pingdi Center for Public Health Service of Longgang District Shenzhen Municipality, Shenzhen, China, [3]Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, [4]Department of Clinical Research, Shenzhen Evergreen Medical Institute, Shenzhen, China, [5]Department of Cardiology, Peking University First Hospital, Beijing, China, [6]Key Laboratory of Precision Nutrition and Food Quality, Ministry of Education, Department of Nutrition and Health, College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing, China, [7]Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, [8]Institute of Biomedicine, Anhui Medical University, Hefei, China, [9]Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, [10]College of Pharmacy, Jinan University, Guangzhou, China, [11]School of Heath Administration, Anhui Medical University, Hefei, China, [12]Department of Neurology, Baoding First Central Hospital, Baoding, China, [13]Yunnan Key Laboratory of Laboratory Medicine, Kunming, China, [14]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China, [15]National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China, [16]Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, China, [17]Guangdong Provincial Engineering Laboratory for Nutrition Translation, Guangzhou, China
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关键词: plasma copper diabetes adults with hypertension Chinese cross-sectional study

摘要:
The relationship between plasma copper concentration and prevalence of diabetes in adults with hypertension is unclear. We aimed to determine the association between plasma copper concentration and prevalence of diabetes in Chinese adults with hypertension.A total of 2,579 participants (697 cases and 1,882 controls) was included in this cross-sectional study. Plasma copper concentrations were determined by inductively coupled plasma mass spectrometry. Multivariable logistic regression model was used to determine the association between plasma copper concentration and prevalence of diabetes.According to the logistic regression analyses, the adjusted OR for the prevalence of diabetes in participants with plasma copper concentration ≥109.4 μg/dL was 1.26 (1.00, 1.58) compared with those with plasma copper concentration <109.4 μg/dL (P = 0.048). The association was no longer significant following further adjusting for serum high-density lipoprotein cholesterol (HDL-C) concentration as a potential confounder. Stratified analyses demonstrated that serum HDL-C concentration significantly modified the association between plasma copper concentration and prevalence of diabetes (P-interaction = 0.043). In the strata of serum HDL-C concentration ≥1.2 mmol/L, a 56% increased prevalence of diabetes was observed in participants with plasma copper concentration ≥109.4 μg/dL compared with those with plasma copper concentration <109.4 μg/dL (P = 0.008). No significant relationship between plasma copper concentration and prevalence of diabetes was found in other strata.Our findings suggested that high plasma copper concentration (≥109.4 μg/dL) was associated with increased prevalence of diabetes in Chinese hypertensive adults with serum HDL-C concentration ≥1.2 mmol/L.Copyright © 2022 Cui, Chen, Lu, Wang, Zhou, Zhang, Wang, Lin, Song, Liu, Huang, Chen, Tang, Gao, Duan, Wang, Zhang, Xu, Yang, Qin and Meng.

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出版当年[2023]版:
大类 | 3 区 医学
小类 | 3 区 公共卫生、环境卫生与职业卫生
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 公共卫生、环境卫生与职业卫生
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出版当年[2022]版:
Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
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Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

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第一作者机构: [1]School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China,
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通讯机构: [1]School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China, [8]Institute of Biomedicine, Anhui Medical University, Hefei, China, [13]Yunnan Key Laboratory of Laboratory Medicine, Kunming, China, [14]Department of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, China, [15]National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China, [16]Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, China, [17]Guangdong Provincial Engineering Laboratory for Nutrition Translation, Guangzhou, China
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