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Integrated bioinformatics analysis for novel miRNAs markers and ceRNA network in diabetic retinopathy

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机构: [1]Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China. [2]Department of Emergency, The First Affiliated Hospital of Kunming Medical University, Kunming, China. [3]Department of Laboratory Animal Science, Kunming Medical University, Kunming, China. [4]Department of Endocrinology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
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关键词: diabetic retinopathy biomarker microarray bioinformatics analysis RNA regulatory pathways

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In order to seek a more outstanding diagnosis and treatment of diabetic retinopathy (DR), we predicted the miRNA biomarkers of DR and explored the pathological mechanism of DR through bioinformatics analysis. Method: Based on public omics data and databases, we investigated ncRNA (non-coding RNA) functions based on the ceRNA hypothesis. Result: Among differentially expressed miRNAs (DE-miRNAs), hsa-miR-1179, -4797-3p and -665 may be diagnosis biomarkers of DR. Functional enrichment analysis revealed differentially expressed mRNAs (DE-mRNAs) enriched in mitochondrial transport, cellular respiration and energy derivation. 18 tissue/organ-specific expressed genes, 10 hub genes and gene cluster modules were identified. The ceRNA networks lncRNA FBXL19-AS1/miR-378f/MRPL39 and lncRNA UBL7-AS1/miR-378f/MRPL39 might be potential RNA regulatory pathways in DR. Conclusion: Differentially expressed hsa-miR-1179, -4797-3p and -665 can be used as powerful markers for DR diagnosis, and the ceRNA network: lncRNA FBXL19-AS1/UBL7-AS1-miR-378f-MRPL39 may represent an important regulatory role in DR progression.Copyright © 2022 Li, Li, Zhao, Wu, Yu, Sun, Ding, Lu, Zhang, Yang, Peng, Fu and Wang.

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出版当年[2023]版:
大类 | 3 区 生物学
小类 | 3 区 遗传学
最新[2023]版:
大类 | 3 区 生物学
小类 | 3 区 遗传学
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Q2 GENETICS & HEREDITY
最新[2023]版:
Q2 GENETICS & HEREDITY

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第一作者机构: [1]Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
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