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1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Niu Lulu[1] ; Li Wenwen[2] ; Chen Xin[1] ; Su Xiaosan[1] ; Dong Jingjing[1] ; Liao Quanyang[1] ; Zhou Xuhong[1,*1] ; Shi Shaoqing[3,*2] ; Sun Ruifen[1,*1] ;
机构： [1]Center for Scientific Research, Yunnan University of Chinese Traditional Medicine, Kunming, Yunnan, People's Republic of China. [2]Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China. [3]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
出处：
DOI： 10.1002/tox.23897
ISSN：

关键词： 1-Mono apoptosis autophagy NSCLC PI3K/Akt

摘要：
Lung cancer is the leading cause of cancer-related death worldwide and non-small cell lung cancer (NSCLC) represents 85%. Mougeotia nummuloides and Spirulina major have been reported to possess anticancer properties. 1-Monopalmitin (1-Mono) is the principle active constituent in these natural plants. It is debating whether 1-Mono exerts antitumor effects. Therefore, we explored the role of 1-Mono in lung cancer in vitro. Results showed that 1-Mono significantly inhibited A549 and SPC-A1 cell proliferation, induced G2/M arrest and caspase-dependent apoptosis. Moreover, it suppressed the protein expression of inhibitors of apoptosis proteins (IAPs). It was further demonstrated that 1-Mono activated the PI3K/Akt pathway, suppression of PI3K/Akt activities with LY294002 and Wortmannin partially attenuated 1-Mono-mediated anticancer activities, indicating that 1-Mono-induced antitumor effects is dependent on PI3K/Akt pathway. 1-Mono induced cytoprotective autophagy since autophagy inhibitor Chloroquine dramatically enhanced 1-Mono-induced cytotoxicity. In summary, our results showed 1-Mono kills lung cancer through PI3K/Akt pathway, providing novel options for lung cancer administration.© 2023 Wiley Periodicals LLC.

基金：
535 Talent Project of First Affiliated Hospital of Kunming Medical University, Grant/Award Number: 2022535Q02; Kunming Medical University Applied basic Research Joint Project, Grant/Award Number: 202201AY070001-092; National Natural Science Foundation of China, Grant/Award Number: 81860412; Yunnan Province High Level Reserve Talents in Health Science, Grant/Award Number: H2018002; Special fund project for central government leading local science and technology development, Grant/Award Number: 202207AB110015; The medical edible flower innovation team of Yunnan colleges and universities, Grant/Award Number: 2020YGC01; Yunnan Fundamental Research Projects, Grant/Award Number: 202201AT070043
语种：
外文
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出版当年[2024]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 2 区 环境科学 2 区 毒理学 2 区 水资源
JCR分区：
出版当年[2023]版：
Q1 TOXICOLOGY Q1 WATER RESOURCES Q2 ENVIRONMENTAL SCIENCES
最新[2023]版：
Q1 TOXICOLOGY Q1 WATER RESOURCES Q2 ENVIRONMENTAL SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Center for Scientific Research, Yunnan University of Chinese Traditional Medicine, Kunming, Yunnan, People's Republic of China.
共同第一作者：
通讯作者：
通讯机构： [1]Center for Scientific Research, Yunnan University of Chinese Traditional Medicine, Kunming, Yunnan, People's Republic of China. [3]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China. [*1]Center for Scientific Research, Yunnan University of Chinese Traditional Medicine, Kunming, Yunnan, 650500, People's Republic of China. [*2]Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, People's Republic of China
推荐引用方式(GB/T 7714)：
Niu Lulu,Li Wenwen,Chen Xin,et al.1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro[J].ENVIRONMENTAL TOXICOLOGY.2023,38(11):2621-2631.doi:10.1002/tox.23897.
APA：
Niu Lulu,Li Wenwen,Chen Xin,Su Xiaosan,Dong Jingjing...&Sun Ruifen.(2023).1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro.ENVIRONMENTAL TOXICOLOGY,38,(11)
MLA：
Niu Lulu,et al."1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro".ENVIRONMENTAL TOXICOLOGY 38..11(2023):2621-2631

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