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Aripiprazole combined with nerve growth factor improves cognitive function in mice with schizophrenia model

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收录情况： ◇ SCIE

作者：
Lu Cailian[1] * ; Li Shan[1] ; Kang Lin[1] ; Li Qianqian[1] ; Chen Hongxu[1] ; Lin Yanwen[1] ; Zhang Han[1] ; Tang Ziling[1] ; Bai Meiyan[1] ; Xiong Peng[1,2,*1] ;
机构： [1]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China [2]Yunnan Clinical Research Center for Mental Health, Kunming, Yunnan, China
出处：
DOI： 10.1016/j.neulet.2023.137410
ISSN：

关键词： Schizophrenia Aripiprazole Nerve growth factor Brain-derived neurotrophic factor Cognitive function

摘要：
The pathogenesis and treatment of cognitive dysfunction in patients with schizophrenia (SCZ) remains a challenge. Exploring new effective treatment strategies is relevant for the improvement of cognitive function. Aripiprazole (ARI) is an atypical antipsychotic that improves some cognitive functions. Nerve growth factor (NGF) has been shown to improve cognitive function in certain neurological impairments and partial neurological deficits, but its mechanism of action in cognitive dysfunction in SCZ is unclear. In this study, we established schizophrenia mouse model with dizocilpine (MK-801); treated mice with ARI alone or in combination with NGF; assessed spontaneous activity and cognitive function using open field test and Morris water maze test; and measured brain-derived neurotrophic factor (BDNF) protein and mRNA expression levels using immunohistochemistry and molecular biology assays. The results showed that ARI alone or in combination with NGF can improve increased spontaneous activity and spatial learning memory deficits in model mice by elevating BDNF expression levels in prefrontal cortex (PFC) and hippocampus (HIP). The results suggest that ARI combined with NGF can improve cognitive function in SCZ, which provides new ideas and directions for the clinical treatment of cognitive dysfunction in SCZ.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
This research was supported by the Science and Technology Research Fund of Yunnan Science and Technology Department of China (Grant No. 202001AY070001-036), the Training Project of Yunnan Highly Level Talents of China (Grant No. RLMY20200023) and the Special Fund of Yunnan Clinical Medical Research Center for Mental and Psychological Diseases of China (Grant No. 202102AA100058).
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外文
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出版当年[2024]版：
无
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 神经科学
JCR分区：
出版当年[2023]版：
Q3 NEUROSCIENCES
最新[2023]版：
Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
通讯作者：
通讯机构： [1]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China [2]Yunnan Clinical Research Center for Mental Health, Kunming, Yunnan, China [*1]Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
推荐引用方式(GB/T 7714)：
Lu Cailian,Li Shan,Kang Lin,et al.Aripiprazole combined with nerve growth factor improves cognitive function in mice with schizophrenia model[J].NEUROSCIENCE LETTERS.2023,812:doi:10.1016/j.neulet.2023.137410.
APA：
Lu Cailian,Li Shan,Kang Lin,Li Qianqian,Chen Hongxu...&Xiong Peng.(2023).Aripiprazole combined with nerve growth factor improves cognitive function in mice with schizophrenia model.NEUROSCIENCE LETTERS,812,
MLA：
Lu Cailian,et al."Aripiprazole combined with nerve growth factor improves cognitive function in mice with schizophrenia model".NEUROSCIENCE LETTERS 812.(2023)

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