个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li Rui[1] * ; Chen Qian[2] ; Cao Xing[3] ; Yan Hua[4] ; Wang Pei[5] ; Huang Qun[6] ; Li Xiaoyi[7] ; Chen Fang[8] ; Li Yangchao[9] ; Kong Qingxia[10] ; Guo Chonglun[11] ; Zhang Qi[12] ; Hong Qiulei[1] ; Liu Yong[13] ; Xiong Xiaoli[14] ; Han Yanbing[15] ; Xiao Xiaohua[16] ; Wang Kuiyun[17] ; Wu Xunyi[18] ; Zhu Xi[19] ; Zhang Qing[20] ; Chen Lei[1] ;
机构： [1]Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [2]Department of Clinical Research Management, West China Hospital of Sichuan University, Chengdu, Sichuan, China. [3]Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China. [4]Department of Neurology, Jianyang People's Hospital, Chengdu, Sichuan, China. [5]Department of Neurology, Xianyang First People's Hospital, Xianyang, Shanxi, China. [6]Department of Pediatrics, The WenJiang Maternal and Child Health Hospital, Chengdu, Sichuan, China. [7]Department of Neurology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China. [8]Department of Neurology, Panzhihua Central Hospital, Panzhihua, Sichuan, China. [9]Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China. [10]Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong, China. [11]Epilepsy Center, Suichuan County People's Hospital, Suichuan, Jiangxi, China. [12]Department of Neurology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Chengdu, Sichuan, China. [13]Department of Neurology, The First Affiliation Hospital of Xi'an Jiaotong University, Xian, Shanxi, China. [14]Department of Neurology, Guangyuan Mental Health Center, Guangyuan, Sichuan, China. [15]Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. [16]Department of Geriatric Medicine, Shenzhen Second People's Hospital, Shenzhen, Guangzhou, China. [17]Department of Neurology, The Jintang First People's Hospital, Chengdu, Sichuan, China. [18]Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China. [19]Department of Neurology, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China. [20]Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
出处：
DOI： 10.3389/fneur.2023.1195003
ISSN：

关键词： seizure women with epilepsy anti-seizure medicine adverse outcome valproate

摘要：
This study aimed to explore the influencing factors of adverse outcomes in the offspring of women with epilepsy (WWE) and to analyze the changes brought about by the epilepsy knowledge popularization campaign in China (EKPCIC).This nested case-control study focused on WWE and their offspring from a female epilepsy cohort in mainland China. From January 2009 to August 2022, WWE was prospectively enrolled in 32 study centers. This study aimed to observe the health outcomes of their offspring within 1 year of age. The main outcome measure assessed the health status of the offspring within their first year of age. We aimed to analyze the effects of seizures, anti-seizure medicines (ASMs), and a lack of folic acid supplementation on adverse outcomes in the offspring of WWE and to explore the changes in perinatal management and adverse outcomes of the offspring after dissemination of the EKPCIC in 2015. Additionally, subgroup analyses were conducted to compare seizure control during pregnancy between the valproate and non-valproate groups.In total, 781 pregnancies in 695 WWE were included, of which 186 (23.69%) had adverse outcomes. The National Hospital Epilepsy Severity Scale score, number of seizures, status epilepticus, ASM type, and valproate and folic acid doses were associated with a high risk of adverse outcomes. After the EKPCIC, the use of ASMs (P = 0.013) and folic acid (P < 0.001), the seizure-free rate during pregnancy (P = 0.013), and the breastfeeding rate (P < 0.001) increased, whereas the incidence of complications during pregnancy decreased (P = 0.013). However, there was no significant difference in the incidence of adverse outcomes between the analyzed offspring pre-/post-EKPCIC. Additionally, there was no association between the frequency of seizures at different time points during pregnancy and the use of valproate (F = 1.514, P = 0.221).Possible factors influencing adverse outcomes in the offspring of WWE include seizures, type and number of ASM usage, and a lack of folic acid supplementation. Although the management of WWE during pregnancy is now more standardized, further efforts are needed to reduce adverse outcomes in offspring.Copyright © 2023 Li, Chen, Cao, Yan, Wang, Huang, Li, Chen, Li, Kong, Guo, Zhang, Hong, Liu, Xiong, Han, Xiao, Wang, Wu, Zhu, Zhang and Chen.

基金：
Med-X Center for Informatics funding project provided fund (YGJC001).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 临床神经病学 3 区 神经科学
JCR分区：
出版当年[2023]版：
Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES
最新[2023]版：
Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Li Rui,Chen Qian,Cao Xing,et al.Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China[J].FRONTIERS IN NEUROLOGY.2023,14:1195003.doi:10.3389/fneur.2023.1195003.
APA：
Li Rui,Chen Qian,Cao Xing,Yan Hua,Wang Pei...&Chen Lei.(2023).Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China.FRONTIERS IN NEUROLOGY,14,
MLA：
Li Rui,et al."Pregnancy characteristics and adverse outcomes in offspring of women with epilepsy: a prospective registry study from Mainland China".FRONTIERS IN NEUROLOGY 14.(2023):1195003

相关文献

[1]Upregulation of Calponin-3 aggravates seizure activity [2]中国围妊娠期女性癫痫患者管理指南 [3]中国围妊娠期女性癫痫患者管理指南 [4]Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy [5]Dynamic functional disturbances of brain network in seizure-related cognitive outcomes [6]Reevaluation of the effect of Dianxianning on seizure rate of refractory epilepsy as additive treatment in clinical practice [7]Anatomy Based Networks and Topology Alteration in Seizure-Related Cognitive Outcomes [8]Acute Sympotomatic Seizure Secondary to Autoimmune Encephalitis and Autoimmune-associated Epilepsy [9]Integrative analysis of rs717620 polymorphism in therapeutic response to anti-seizure medications [10]超快速液相色谱-串联质谱法测定人血浆中的丙戊酸

资源点击量：56763 今日访问量：0 总访问量：1769 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 昆明医科大学第一附属医院 技术支持：重庆聚合科技有限公司 地址：云南省昆明市西昌路295号(650032)