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Disordered gut microbiota and alterations in the serum metabolome are associated with venous thromboembolism

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机构： [1]Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, Kunming, China [2]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, China

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关键词： Venous thromboembolism Gut microbiota Metabolome

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The gut microbiome plays a crucial role in various diseases, and its regulation is a potential treatment option for these conditions. However, the relationship between the gut microbiome and venous thromboembolism (VTE) remains poorly explored.In this study, we collected feces and serum samples from 8 VTE patients and 7 healthy controls. The gut microbiota and serum metabolites were analyzed using 16S rRNA gene sequencing and liquid chromatography-mass spectrometry, respectively. Additionally, a combined analysis of microbiota and metabolome was performed.The alpha and beta diversity between the VTE and control groups were significantly different. Patients with VTE exhibited an overgrowth of Blautia, Roseburia, Coprococcus, and Ruminococcus. Moreover, serum metabolomics analysis revealed altered levels of choline and lithocholic acid. Pathway enrichment analysis indicated a significant upregulation of bile secretion pathways. In addition, a positive correlation was observed between the levels of serum choline and lithocholic acid and the abundance of gut flora enriched in the VTE group.This study provided novel insights into the disordered gut microbiota and serum metabolome associated with VTE, suggesting potential common pathological mechanisms between VTE and arterial thrombosis. Targeted modulation of the gut microbiome may hold promise as a preventive and therapeutic approach for VTE.Copyright © 2024. Published by Elsevier Ltd.

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大类 | 3 区医学

小类 | 3 区血液学 3 区外周血管病

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出版当年[2024]版：

无

最新[2023]版：

Q1 HEMATOLOGY Q1 PERIPHERAL VASCULAR DISEASE

影响因子： 3.7 最新[2023版] 4.1 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 3.7 出版前一年[2023版]

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第一作者机构： [1]Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Yunnan University, Kunming, China

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通讯机构： [2]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, China

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