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Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

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机构： [1]Department of Dermatology and Venereology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China. [2]Kunming Biological Diversity Regional Center of Large Apparatus and Equipments, Public Technical Service Center, Kunming Institute of Zoology, Kunming 650223, Yunnan Province, China. [3]School of Stomatology, Kunming Medical University, Kunming 650500, Yunnan Province, China. [4]Genome Center of Biodiversity, Kunming Institute of Zoology, Chinese Academy of Science, Kunming 650223, Yunnan Province, China. [5]Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.

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关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes

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Aberrant methylation is common during the initiation and progression of colorectal cancer (CRC), and detecting these changes that occur during early adenoma (ADE) formation and CRC progression has clinical value.To identify potential DNA methylation markers specific to ADE and CRC.Here, we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic landscape.Comparing 22 CRC and 25 ADE samples, global methylation was higher in the former, but both showed similar methylation patterns regarding differentially methylated gene positions, chromatin signatures, and repeated elements. High-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade CRC. Combined with RNA-seq gene expression data, we identified 14 methylation-regulated differentially expressed genes, of which only AGTR1 and NECAB1 methylation had prognostic significance.Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC, suggesting prognostic biomarkers for CRC.©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

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基金编号： 81960504; RLQB20200002; H-2018015

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大类 | 4 区医学

小类 | 4 区胃肠肝病学 4 区肿瘤学

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Q2 GASTROENTEROLOGY & HEPATOLOGY Q3 GASTROENTEROLOGY & HEPATOLOGY Q3 ONCOLOGY

影响因子： 2.5 最新[2023版] 2.8 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 2.5 出版前一年[2023版]

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第一作者机构： [1]Department of Dermatology and Venereology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.

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