Activation of the phosphoinositide 3 kinase (PI3K)/AKT pathway is frequently implicated in resistance to anti cancer therapies. PI3K inhibitors can restore sensitivity to standard breast cancer therapies, including endocrine therapy, HER2-targeted agents, and chemotherapy. Our previous research showed that econazole, a novel PI3Ka Inhibitor, inhibits the PI3K/AKT pathway and induces apoptosis in lung cancer cells. In this study, econazole showed significant cytotoxic activity against Adriamycin-resistant breast cancer cells in vitro and in vivo. Additionally, econazole significantly sensitized MDA-MB-231 and MCF-7 cells to Adriamycin via inhibiting the PI3K/AKT pathway. Overexpression of constitutively active AKT1 abolished the function of econazole. The combination of econazole and Adriamycin exerted synergistic inhibitory effects in breast cancer cells in vitro and in vivo. Taken together, the PI3K inhibitor econazole could effectively overcome Adriamycin resistance and showed synergistic effects with chemotherapy on breast cancer.
基金：
National Key R&D Program of China [2018-YFC2000400]; National Nature Science Foundation of ChinaNational Natural Science Foundation of China [81830087, U1602221, 31771516]; Science and Technology Innovation Team of Yunnan Province [2018HC002]; top young talents of ten thousand talents plan in Yunnan Province; medical reserve personnel training program of Yunnan province [H-201609]; General Research Projects in Yunnan Province [2019FB113]; Health Science and technology project of Yunnan province [2018NS0052]; Hundred-Talent Program of Kunming Medical University [60118260119]; Yunnan Provincial Science and Technology Department; Yunnan Province Science and Technology Department-Kunming Medical University Joint Fund for Fundamental Research [2019FE0-01-064, 2019FE001-082]
第一作者机构：[1]Kunming Med Univ, Yunnan Tumor Hosp, Affiliated Hosp 3, Dept Med Oncol 2, Kunming, Yunnan, Peoples R China
通讯作者：
通讯机构：[8]Chinese Acad Sci, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, 32 Jiaochang East Rd, Kunming 650223, Yunnan, Peoples R China[11]Zhengzhou Univ, Acad Med Sci, Inst Med & Pharmaceut Sci, Sci Ave 100, Zhengzhou 450001, Henan, Peoples R China
推荐引用方式(GB/T 7714)：
Dong Chao,Chen Yin,Ma Jing,et al.Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway[J].AMERICAN JOURNAL OF CANCER RESEARCH.2020,10(1):263-274.
APA：
Dong, Chao,Chen, Yin,Ma, Jing,Yang, Runxiang,Li, Hongjian...&Chen, Ceshi.(2020).Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway.AMERICAN JOURNAL OF CANCER RESEARCH,10,(1)
MLA：
Dong, Chao,et al."Econazole nitrate reversed the resistance of breast cancer cells to Adriamycin through inhibiting the PI3K/AKT signaling pathway".AMERICAN JOURNAL OF CANCER RESEARCH 10..1(2020):263-274
