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GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma

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收录情况： ◇ SCIE

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机构： [1]Department of Bone and Soft Tissue Neurosurgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China [2]Department of Orthopedics, First Central Clinical College, Tianjin Medical University, Nankai District 300110, Tianjin, China. [3]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China.

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关键词： lncRNA GAPLINC osteosarcoma biomarker metastasis

摘要：

Gastric adenocarcinoma predictive long intergenic non-coding (GAPLINC) is a novel long non-coding RNA (lncRNA) and has been found to function as an oncogenic lncRNA in gastric cancer, colorectal cancer, and bladder cancer. The expression status and biological function of GAPLINC in osteosarcoma are still unknown. Thus, we analyzed the association between GAPLINC expression and clinicopathological characteristics in osteosarcoma clinical samples, and conducted loss-of-function study in osteosarcoma cell lines. In our results, GAPLINC expression is elevated in osteosarcoma tissues and cell lines, and correlated with advanced Enneking stage, present distant metastasis, and poor histological grade. Survival analyses indicated that GAPLINC expression was negatively associated with overall survival, and GAPLINC high-expression was an independent risk factor in osteosarcoma patients. The in vitro studies showed knockdown of GAPLINC depressed osteosarcoma cell migration and invasion via inhibiting CD44 expression, but no effect on cell proliferation. In conclusion, GAPLINC may serve as a potential biomarker for predicting prognosis and developing therapy for osteosarcoma.

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出版当年[2019]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区细胞生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

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出版当年[2018]版：

Q3 CELL BIOLOGY Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY

影响因子： 3.8 最新[2023版] 3.5 最新五年平均 2.535 出版当年[2018版] 2.939 出版当年五年平均 2.899 出版前一年[2017版] 2.942 出版后一年[2019版]

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第一作者机构： [1]Department of Bone and Soft Tissue Neurosurgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China

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通讯机构： [*1]Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, No.295 Xichang Road, Kunming 650032, Yunnan, China

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