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Expression of microRNAs in thyroid carcinoma

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机构： [a]Department of Nuclear Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China [b]School of Computing, University of South Alabama, Mobile, AL 36688, United States

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关键词： Gene expression MicroRNA Thyroid cancer

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MicroRNA (miRNA) are negative regulators of gene expression and subsequent protein production. This method of action translates into regulatory control over cellular processes, including development, signaling, metabolism, and apoptosis. A broad range of miRNA are shown to have abnormal expressions in thyroid cancers which could explain the pathology of tumor oncogenesis and disease progression. A review is conducted of the current research on miRNA dysregulation in thyroid cancers, including papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), anaplastic thyroid cancer (ATC), and medullary thyroid carcinoma (MTC). Dysregulated miRNA and their associated regulatory pathways are identified and their oncogenic and pathological significance are discussed. © Springer Science+Business Media LLC 2017.

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第一作者机构： [a]Department of Nuclear Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China

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