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The association of the heterogeneity of HBV reverse transcriptase quasispecies with antiviral efficacy after treatment with nucleos(t)ide analogues for 10 years

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收录情况： ◇ SCIE

作者：
Zhou, T.-C[1] ; Liu, F.-W[1] ; Fan, J.-H[1,2] ; Zhang, S.-H[1] ; Lv, S.-Q[3] ; Yu, Z.-Y[4] ; Zhang, Y.-M[2] ; Zhang, L[1] ; Wei, J[1] ;
机构： [1]Central Lab, Liver Disease Research Center, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China [2]The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China [3]Clinical Lab, The Third People’s Hospital of Kunming City, Kunming, Yunnan Province, China [4]Hepatopancreatobiliary Surgery Department, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China
出处：
DOI： 10.1016/j.meegid.2021.104706
ISSN：

关键词： Antiviral efficacy hepatitis B virus (HBV) Heterogeneity Nucleos(t)ide analogues (NAs) Reverse transcriptase (RT)

摘要：
To assess the heterogeneity of HBV reverse transcriptase (RT) quasispecies during 10 years of antiviral therapy and their association with antiviral efficacy. Nineteen patients with chronic hepatitis B (CHB) infection receiving nucleos(t)ide analogues (NAs) were enrolled. Based on the antiviral efficacy after 1 year of treatment, 5 patients were grouped into an early virologic response (EVR) group, while 8 patients were grouped into a late virologic response (LVR) group. Furthermore, 6 CHB patients that had undergone antiviral treatment for 10 years were grouped into a virologic breakthrough (VBT) group. The HBV RT from each patient were amplified, cloned, and sequenced. The complexity of the RT gene in the EVR group was significantly higher than that in the LVR (P = 0.0393) and VBT groups (P = 0.0141). Phylogenetic tree analysis showed that the average branch length of the EVR and LVR groups were significantly greater than that of VBT group (P < 0.001). The complexity (at the nucleotide level) of the RT quasispecies was negatively correlated with the corresponding HBV DNA load (P = 0.0163) at one year post-antiviral treatment. Moreover, both the LVR and VBT groups accumulated more deleterious mutations than the EVR group. After 1 year of NAs treatment, the increased HBV quasispecies complexity and evolutionary topologies, coupled with less deleterious mutations, are likely associated with a favorable efficacy during long-term antiviral treatment. © 2021 Elsevier B.V.

基金：
We are grateful to all of the participants for their willingness to participate in this study. This work was supported by grants from the Yunnan Natural Science Foundation ( 202001AT070085 , China), Health Research Institution Project of Yunnan Province ( 2018NS0003 , China), Major Science and Technology Special Project of Yunnan Province (Biomedicine) ( 202003AC100010 , China), High-level Health Technical Personnel Project of Yunnan Province ( H-2018102 , China), Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Fund ( 2019FE001(-195) , China), and National Natural Science Foundation of China ( 81960116; 82060368 , China).
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外文
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出版当年[2022]版：
大类 | 3 区 医学
小类 | 4 区 传染病学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 传染病学
JCR分区：
出版当年[2021]版：
Q2 INFECTIOUS DISEASES
最新[2023]版：
Q3 INFECTIOUS DISEASES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Central Lab, Liver Disease Research Center, The Second People’s Hospital of Yunnan Province, Kunming, Yunnan Province, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou T.-C,Liu F.-W,Fan J.-H,et al.The association of the heterogeneity of HBV reverse transcriptase quasispecies with antiviral efficacy after treatment with nucleos(t)ide analogues for 10 years[J].INFECTION GENETICS AND EVOLUTION.2021,89:doi:10.1016/j.meegid.2021.104706.
APA：
Zhou, T.-C,Liu, F.-W,Fan, J.-H,Zhang, S.-H,Lv, S.-Q...&Wei, J.(2021).The association of the heterogeneity of HBV reverse transcriptase quasispecies with antiviral efficacy after treatment with nucleos(t)ide analogues for 10 years.INFECTION GENETICS AND EVOLUTION,89,
MLA：
Zhou, T.-C,et al."The association of the heterogeneity of HBV reverse transcriptase quasispecies with antiviral efficacy after treatment with nucleos(t)ide analogues for 10 years".INFECTION GENETICS AND EVOLUTION 89.(2021)

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